Lung Health and the Microbiome Among Adults in Botswana: the Go-hema Cohort
Recruiting · NCT07699614 · Observational (researchers observe without assigning treatment) · Lead sponsor: Duke University
View the official record on ClinicalTrials.gov →What this trial is about
Chronic respiratory diseases like chronic obstructive pulmonary disease (COPD) are responsible for millions of deaths each year, the majority of which occur in low- and middle-income countries (LMICs). LMICs also have high rates of abnormal lung function, including restrictive spirometric pattern (RSP), which can precede the development of chronic respiratory diseases and is associated with all-cause mortality. Additionally, LMICs in sub-Saharan Africa are home to the majority of the world's population of people with HIV (PWH). HIV increases the risk of COPD and COPD associated mortality, but the mechanisms underlying this risk are incompletely understood.
Who can take part
Inclusion criteria
- Adults 35 years of age or older
- In case at a clinic in Botswana
- Documented HIV status
- Ability to provide informed consent
Exclusion criteria
- Respiratory infection in the prior 4 weeks
- Active pulmonary tuberculosis
- Inability to perform spirometry including eye, abdominal, or
- Thoracic surgery or myocardial infarction in the prior 6 weeks
- Pregnancy
Where it is running
1 location listed.
- Local Health Facilities in Gaborone - Gaborone, Botswana