Bariatric Surgery Combined With GLP-1RA: A Multicenter Study.
Recruiting · NCT07732738 · Interventional (participants receive a specific treatment)
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Obese patients exhibit considerable heterogeneity and complex comorbidities, making long-term effective management challenging with single therapies. While bariatric surgery remains the most effective weight-loss intervention, postoperative weight regain and metabolic deterioration require attention. GLP-1 RAs offer distinct advantages for weight and metabolic improvement, and their combined application with surgery may yield synergistic benefits. Given the lack of multi-regional validation in China's diverse population, this multicenter study aims to confirm the real-world effectiveness and generalizability of bariatric surgery plus GLP-1RA across distinct regional cohorts.
Who can take part
Inclusion criteria
- Primary metabolic surgery candidates: Patients undergoing initial laparoscopic sleeve gastrectomy (LSG).
- obesity:BMI ≥27.5 kg/m².
- Metabolic comorbidities: Diagnosis of metabolic syndrome or type 2 diabetes mellitus (T2DM) meeting standard criteria.
- Age range: 16-70 years (inclusive).
- Informed consent: Willing participation with documented consent.
Exclusion criteria
- Recent GLP-1RA use: Treatment with GLP-1 receptor agonists within 6 months preoperatively.
- Prior bariatric surgery: History of any metabolic/bariatric surgical procedure.
- Postoperative complications: Requiring reoperation for severe complications (e.g., hemorrhage, anastomotic leak).
- Non-indicated candidates: Patients not meeting standard bariatric surgery indications.
- Significant comorbidities:
- Advanced hepatic/renal dysfunction (Child-Pugh C or eGFR \<30 mL/min/1.73m²) Active malignancy (except non-melanoma skin cancers) Autoimmune disorders requiring immunosuppression Uncontrolled psychiatric conditions (e.g., active psychosis, severe depression)
Where it is running
7 locations listed.
- China-Japan Friendship Hospital - Beijing, China
- Xingtai Ninth Hospital - Xingtai, Hebei, China
- Zhengzhou Central Hospita - Zhengzhou, Henan, China
- The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology - Baotou, Inner Mongolia, China
- The Second Hospital, Cheeloo College of Medicine, Shandong University - Jinan, Shandong, China
- Sinopharm Tongmei General Hospital - Datong, Shanxi, China
- The First People Hospital Of Yunnan Province - Kunming, Yunnan, China