A Study to Evaluate Effect of AZD6234 in Adult Participants With Obesity or Overweight With Weight-related Comorbidity Without Type 2 Diabetes Mellitus

Recruiting · NCT07784725 · Interventional (participants receive a specific treatment) · Lead sponsor: AstraZeneca

View the official record on ClinicalTrials.gov →

Interventions studied

What this trial is about

The study will evaluate how well AZD6234 works and how safe it is in adults with excess weight or obesity. Efficacy of AZD6234 will be compared to placebo in percent body weight change from baseline at 68 weeks of treatment

Who can take part

Age range

18 Years and older

Sex

All (male and female)

Healthy volunteers

No - a diagnosis or condition is required

Phase

Phase 3

Study type

Interventional (participants receive a specific treatment)

Inclusion criteria

Males \& females (inclusive of all gender identities) age ≥18 years
BMI ≥30 kg/m2 OR BMI ≥27 kg/m2 with at least one of the following weight related comorbidities (treated or untreated): hypertension, dyslipidaemia, obstructive sleep apnoea, cardiovascular disease, heart failure, chronic kidney disease, metabolic dysfunction-associated steatotic liver disease, osteoarthritis of the knee, or stress urinary incontinence
Stable body weight (≤5% body weight change) for at least 3 months prior to Randomisation
History of at least one self-reported unsuccessful attempt to lose body weight in their lifetime

Exclusion criteria

Obesity primarily caused by other endocrine disorders
History of Type 1 or Type 2 Diabetes Mellitus, HbA1c ≥6.5% (48 mmol/mol), and/or treatment with glucose-lowering agent(s) within 3 months prior to Screening
Significant hepatobiliary disease and/or any of the following results at Screening:
ALT ≥ 3.0 × ULN
AST ≥ 3.0 × ULN
TBL \> 1.5 × ULN (except for cases of known Gilbert's Syndrome)
Has received treatment with a GLP-1 receptor agonist or GLP-1 containing medication for any indication within 3 months before Randomisation.

Where it is running

60 locations listed across 24 US states.

Research Site - Dothan, Alabama, United States
Research Site - Huntsville, Alabama, United States
Research Site - Mesa, Arizona, United States
Research Site - Escondido, California, United States
Research Site - Clearwater, Florida, United States
Research Site - Jacksonville, Florida, United States
Research Site - Stockbridge, Georgia, United States
Research Site - Champaign, Illinois, United States
Research Site - Chicago, Illinois, United States
Research Site - Ames, Iowa, United States
Research Site - Troy, Michigan, United States
Research Site - Jefferson City, Missouri, United States
Research Site - Kansas City, Missouri, United States
Research Site - Butte, Montana, United States
Research Site - Las Vegas, Nevada, United States
Research Site - Jersey City, New Jersey, United States
Research Site - Cortland, New York, United States
Research Site - Statesville, North Carolina, United States
Research Site - Fargo, North Dakota, United States
Research Site - Columbus, Ohio, United States
Research Site - Tulsa, Oklahoma, United States
Research Site - Portland, Oregon, United States
Research Site - Philadelphia, Pennsylvania, United States
Research Site - Smithfield, Pennsylvania, United States
Research Site - Kingsport, Tennessee, United States
Research Site - Houston, Texas, United States
Research Site - San Antonio, Texas, United States
Research Site - Sugar Land, Texas, United States
Research Site - Waco, Texas, United States
Research Site - Salt Lake City, Utah, United States
Research Site - Arlington, Virginia, United States
Research Site - Renton, Washington, United States
Research Site - Seattle, Washington, United States
Research Site - Anyang, South Korea
Research Site - Beijing, China
Research Site - Belo Horizonte, Brazil
Research Site - Benešov, Czechia
Research Site - Berlin, Germany
Research Site - Berlin, Germany
Research Site - Berlin, Germany
Research Site - Bhubaneswar, India
Research Site - Bialystok, Poland
Research Site - Bobigny, France
Research Site - Bochum, Germany
Research Site - Bologna, Italy
Research Site - Botany, Australia
Research Site - Brandýs nad Labem, Czechia
Research Site - Brasília, Brazil
Research Site - Brno, Czechia
Research Site - Bucheon-si, South Korea
Research Site - Buenos Aires, Argentina
Research Site - Bünde, Germany
Research Site - CABA, Argentina
Research Site - Campinas, Brazil
Research Site - Campinas, Brazil
Research Site - Cangzhou, China
Research Site - Changchun, China
Research Site - Changchun, China
Research Site - Changhua, Taiwan
Research Site - Changsha, China

Showing 60 of 212 listed sites. See the official record for the complete list.

Read the full protocol, contacts and eligibility on ClinicalTrials.gov →