Study of NXP900 With Lorlatinib in ALK+ Lung Cancer
Recruiting · NCT07784959 · Interventional (participants receive a specific treatment)
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
This is a multi-center, open label, Phase 1b study of NXP900 in combination with lorlatinib in subjects with advanced, ALK-positive non-small cell lung cancer (NSCLC)
Who can take part
Age range
No age limits stated
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 1
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- 18 years old or older
- Unresectable, metastatic or locally advanced ALK-positive NSCLC.
- Must have received lorlatinib as first or second line TKI
- One prior line of systemic chemotherapy is permitted
- Must have tolerated the dose level of lorlatinib actively being explored in the study or a higher dose
Exclusion criteria
- Known single or compound ALK domain mutations that cause resistance to lorlatinib, or known actionable oncogenic driver alterations other than ALK with approved targeted therapies available, such as, MET or EGFR mutations or HER2 overexpression
- Any contraindications to treatment with lorlatinib according to the lorlatinib United States Prescribing Information (USPI)
Where it is running
1 location listed across 1 US state.
- NEXT Virginia - Fairfax, Virginia, United States