Usefulness of Thromboelastography as a Predictor of Prognosis in Patients Undergoing Surgery for Glial Tumors and of the Risk of Postoperative Thromboembolic Disease (GliTEM)
Recruiting · NCT07813377 · Observational (researchers observe without assigning treatment)
View the official record on ClinicalTrials.gov →Interventions studied
Thromboelastometry values: EXTEM CT, MCF, α-angle below the lower limit of normal. Measurement obtained after anesthetic induction. - PT, aPTT, fibrinogen, platelet count. - Thrombin generation. -
What this trial is about
The objective of our study is to investigate the clinical significance of thromboelastometric values in the development of thrombotic events and survival in patients with glial tumors, to reduce thromboembolic complications and optimize oncological treatment.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Patients undergoing surgical excision or biopsy with a diagnostic impression of glial tumor who provide written informed consent
Exclusion criteria
- Patients under 18 years of age.
- Emergency surgery.
- Patients receiving antiplatelet or anticoagulant treatment.
- Patients with known hematologic diseases associated with coagulation abnormalities. Examples include:
- Congenital or acquired platelet function disorders.
- Congenital deficiency of protein C or protein S.
- Deficiency of coagulation factors II, V, VII, X, XII.
- Glanzmann thrombasthenia.
- Hemophilia A, B, or C.
- Idiopathic thrombocytopenic purpura (ITP).
- von Willebrand disease (types I, II, and III).
- Systemic diseases that cause significant coagulation time alterations:
- Prothrombin time \< 60%.
- Activated partial thromboplastin time (aPTT) \> 50 seconds.
- Patients with suspected glial or neuroglial tumor in the context of long-standing epilepsy
Where it is running
1 location listed.
- Hospital Clínic Barcelona - Barcelona, Spain