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A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)
NCT07033494 ·
Phase: Phase 2 ·
Ages: 50 Years to 85 Years ·
Sex: All (male and female)
· Florida: Atlantis, Fort Myers, Maitland, Melbourne
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A Clinical Trial of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease
NCT07170150 ·
Phase: Phase 3 ·
Ages: 50 Years to 90 Years ·
Sex: All (male and female)
· Florida: Atlantis, Clermont, Miami, Orlando
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A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease
NCT07094516 ·
Phase: Phase 2 ·
Ages: 50 Years to 85 Years ·
Sex: All (male and female)
· Florida: Atlantis, Aventura, Maitland, Ocala
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A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease
NCT06297590 ·
Phase: Phase 1 ·
Ages: 50 Years to 85 Years ·
Sex: All (male and female)
· Florida: Maitland, The Villages
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A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease
NCT07011745 ·
Phase: Phase 3 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Florida: Aventura, Bonita Springs, Bradenton, Doral
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A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)
NCT07011732 ·
Phase: Phase 3 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Florida: Maitland, Merritt Island, Miami, Ocala
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A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT).
NCT07602582 ·
Phase: Phase 3 ·
Ages: 55 Years and older ·
Sex: All (male and female)
· Florida: Aventura, Bradenton, Greenacres City, Jacksonville
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A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)
NCT07589595 ·
Phase: Phase 2 ·
Ages: 55 Years to 85 Years ·
Sex: All (male and female)
· Florida: Atlantis, Aventura, Delray Beach, Fort Myers
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A Study of LY3439539 in Participants With Alzheimer's Disease
NCT07598370 ·
Phase: Phase 1 ·
Ages: 50 Years to 85 Years ·
Sex: All (male and female)
· Florida: Orlando
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A Study of LY4006895 in Healthy Participants With Early Symptomatic Alzheimer's Disease (AD)
NCT06657768 ·
Phase: Phase 1 ·
Ages: 45 Years to 85 Years ·
Sex: All (male and female)
· Florida: Lady Lake, Maitland, Naples, Port Orange
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A Study of Trontinemab in Cognitively Unimpaired Individuals at Risk for Progression to Symptomatic Alzheimer's Disease
NCT07717411 ·
Phase: Phase 3 ·
Ages: 55 Years to 80 Years ·
Sex: All (male and female)
· Florida: Maitland
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A Study of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease
NCT07169578 ·
Phase: Phase 3 ·
Ages: 50 Years to 90 Years ·
Sex: All (male and female)
· Florida: Lady Lake, Maitland, Ocala, Tampa
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A Study of Zunveyl on Safety, Tolerability, Neuropsychiatric Symptoms, and Caregiver Distress in Alzheimer's Disease (RESOLVE)
NCT07633470 ·
Phase: Phase 4 ·
Ages: 50 Years and older ·
Sex: All (male and female)
· Florida: Aventura, Hialeah, Melbourne, Miami
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A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-1)
NCT05511363 ·
Phase: Phase 3 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Florida: Boca Raton, Bonita Springs, Bradenton, Clermont
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A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-2)
NCT06126224 ·
Phase: Phase 3 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Florida: Apopka, Clermont, Cutler Bay, Delray Beach
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A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)
NCT05462106 ·
Phase: Phase 1, Phase 2 ·
Ages: 35 Years to 85 Years ·
Sex: All (male and female)
· Florida: Lady Lake, Orlando, The Villages
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A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Agitation Associated With Alzheimer's Dementia
NCT06651567 ·
Phase: Phase 2 ·
Ages: 55 Years and older ·
Sex: All (male and female)
· Florida: Boca Raton, Bonita Springs, Brandon, Delray Beach
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A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Psychosis Associated With Alzheimer's Disease
NCT06540833 ·
Phase: Phase 2 ·
Ages: 55 Years and older ·
Sex: All (male and female)
· Florida: Bonita Springs, Brandon, Coral Springs, Delray Beach
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A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Alzheimer's Disease Psychosis
NCT06887192 ·
Phase: Phase 2 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Florida: Boca Raton, Deerfield Beach, Doral, Homestead
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A Study to Assess the Safety and Effects of ABBV-1758 Following Subcutaneous or Intravenous Injections in Participants With Alzheimer's Disease
NCT07599670 ·
Phase: Phase 1, Phase 2 ·
Ages: 50 Years to 90 Years ·
Sex: All (male and female)
· Florida: Bradenton, Clermont, Lady Lake, Stuart
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A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)
NCT06585787 ·
Phase: Phase 3 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Florida: Atlantis, Bonita Springs, Cutler Bay, Daytona Beach
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A Study to Evaluate Mivelsiran in Adult Participants With Early-Stage Down Syndrome-Associated Alzheimer's Disease (DS-AD)
NCT07636811 ·
Phase: Phase 2 ·
Ages: 40 Years to 55 Years ·
Sex: All (male and female)
· Florida: Maitland, Naples
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A Study to Evaluate Safety and Efficacy of KarXT + KarX-EC as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-5)
NCT06947941 ·
Phase: Phase 3 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Florida: Naples
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A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease
NCT06976216 ·
Phase: Phase 3 ·
Ages: 60 Years to 85 Years ·
Sex: All (male and female)
· Florida: Atlantis, Aventura, Merritt Island, Ocala
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A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)
NCT06976203 ·
Phase: Phase 3 ·
Ages: 60 Years to 85 Years ·
Sex: All (male and female)
· Florida: Fort Myers, Hallandale, Jacksonville, Lady Lake
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A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)
NCT06937229 ·
Phase: Phase 3 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Florida: Bonita Springs, Miami, Orlando, Port Orange
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A Study to Investigate the Safety and Effectiveness of SAR448851 in Participants With Early Alzheimer's Disease
NCT07688213 ·
Phase: Phase 2 ·
Ages: 55 Years to 85 Years ·
Sex: All (male and female)
· Florida: The Villages
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ACP-204 in Adults With Alzheimer's Disease Psychosis
NCT06159673 ·
Phase: Phase 2, Phase 3 ·
Ages: 55 Years to 95 Years ·
Sex: All (male and female)
· Florida: Aventura, Daytona Beach, Doral, Hialeah
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AV-1980R (Tau Vaccine) in Preclinical Alzheimer's Disease (TAURUS-1980)
NCT07158905 ·
Phase: Phase 1 ·
Ages: 65 Years to 80 Years ·
Sex: All (male and female)
· Florida: Boca Raton, Miami Lakes, Stuart, Tampa
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Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
NCT06563895 ·
Phase: Phase 3 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Florida: Jacksonville, Miami, Weston
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Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy
NCT03657745 ·
Phase: Not specified ·
Ages: 50 Years and older ·
Sex: All (male and female)
· Florida: Miami
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An Open Label Dose Escalation Study of VY1706 in Participants With Early Alzheimer's Disease
NCT07764146 ·
Phase: Phase 1 ·
Ages: 30 Years to 80 Years ·
Sex: All (male and female)
· Florida: Maitland
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Anxiety Sensitivity Treatment to Reduce Anxiety in Alzheimer's
NCT05748613 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 60 Years and older ·
Sex: All (male and female)
· Florida: Tallahassee
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Brain NAD in Alzheimer's Disease
NCT07127510 ·
Phase: Not specified ·
Ages: 65 Years to 80 Years ·
Sex: All (male and female)
· Florida: Boca Raton
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Clinical Study of SNK01 in Participants With Moderate Alzheimer's Disease
NCT06189963 ·
Phase: Phase 1, Phase 2 ·
Ages: 40 Years to 85 Years ·
Sex: All (male and female)
· Florida: Maitland, Orlando
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Clinical Trial on Agitation in Alzheimer's Dementia
NCT05543681 ·
Phase: Phase 2 ·
Ages: 60 Years and older ·
Sex: All (male and female)
· Florida: Maitland, Melbourne, Miami, Port Charlotte
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Combating Alzheimer's Through Sleep and Exercise
NCT04855630 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 45 Years to 80 Years ·
Sex: All (male and female)
· Florida: Miami
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Development of a Database to Investigate Digital and Blood-Based Biomarkers and Their Relationship to Tau and Amyloid PET Imaging in Older Participants Who Are Cognitively Normal (CN), Have Mild Cognitive Impairment (MCI), or Have Mild-to-Moderate AD Dementia
NCT06584357 ·
Phase: Not specified ·
Ages: 60 Years to 90 Years ·
Sex: All (male and female)
· Florida: Atlantis, Aventura, Clermont, Delray Beach
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Dexmedetomidine Transdermal Systems (DMTS) Treatment for Agitation Associated With Dementia of the Alzheimer's Type
NCT06052254 ·
Phase: Phase 2 ·
Ages: No age limits stated ·
Sex: All (male and female)
· Florida: Daytona Beach, Delray Beach, Miami, St. Petersburg
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Dominantly Inherited Alzheimer Network (DIAN)
NCT00869817 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Jacksonville
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Dynamic Light Scattering Ocular Measurement in the Detection of Dementia
NCT06613971 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Coconut Creek
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ExAblate Blood-Brain Barrier (BBB) Disruption for the Treatment of Alzheimer's Disease
NCT03671889 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 50 Years to 85 Years ·
Sex: All (male and female)
· Florida: Delray Beach, Fort Lauderdale, Gainesville, Miami
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Human Mesenchymal Stem Cells & Monoclonal Antibodies in the Treatment for Mild Cognitive Impairment or Early Alzheimer's Disease.
NCT07512362 ·
Phase: Phase 2 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Florida: Miami
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Human Mesenchymal Stem Cells (hMSC) in Behavioral Problems Due to Alzheimer's Disease.
NCT06781333 ·
Phase: Phase 2 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Florida: Miami
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Late Onset Alzheimer's Disease
NCT05010603 ·
Phase: Not specified ·
Ages: 55 Years and older ·
Sex: All (male and female)
· Florida: Miami
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Longitudinal Cognitive Assessment by BoCA
NCT04114994 ·
Phase: Not specified ·
Ages: 50 Years and older ·
Sex: All (male and female)
· Florida: Miami
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Low-Dose Radiotherapy for Alzheimer's Disease
NCT07693140 ·
Phase: Phase 1, Phase 2 ·
Ages: 50 Years and older ·
Sex: All (male and female)
· Florida: Winter Park
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Masupirdine for the Treatment of Agitation in Dementia of the Alzheimer's Type
NCT05397639 ·
Phase: Phase 3 ·
Ages: 50 Years to 90 Years ·
Sex: All (male and female)
· Florida: Miami, Orlando, Pompano Beach
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Microbiome in Aging of Gut and Brain
NCT07799402 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Tampa
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Neurologic Stem Cell Treatment Study
NCT02795052 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Florida: Coral Springs
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Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)
NCT05980949 ·
Phase: Phase 3 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Florida: Atlantis, Boca Raton, Bonita Springs, Bradenton
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Open-label Extension Study in Participants With Early Alzheimer's Disease
NCT07105709 ·
Phase: Phase 2 ·
Ages: 50 Years to 85 Years ·
Sex: All (male and female)
· Florida: Maitland, Miami, Stuart
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Palliative Care Education in Assisted Living for Dementia Care Providers (PCEAL-DCP)
NCT06722352 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 21 Years and older ·
Sex: All (male and female)
· Florida: Tampa
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Personalized Obstructive Sleep Apnea Treatment and Effects on Alzheimer's Disease Biomarkers and Cognition Among Blacks
NCT06089161 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 60 Years to 85 Years ·
Sex: All (male and female)
· Florida: Miami
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Pulsed Electromagnetic Field Treatment With Dementia Patients
NCT06862557 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 50 Years to 100 Years ·
Sex: All (male and female)
· Florida: Boca Raton
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Robotic-Enabled Microsurgical Intervention for Neurodegenerative Disease
NCT07178210 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 50 Years and older ·
Sex: All (male and female)
· Florida: Jacksonville
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Safety, PK and Biodistribution of 18F-OP-801 in Patients With ALS, AD, MS, PD and Healthy Volunteers
NCT05395624 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female)
· Florida: Jacksonville
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Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies
NCT07177352 ·
Phase: Phase 3 ·
Ages: 50 Years to 90 Years ·
Sex: All (male and female)
· Florida: Atlantis, Clermont, Lady Lake, Maitland
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Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's Disease
NCT03821857 ·
Phase: Phase 4 ·
Ages: 60 Years and older ·
Sex: Female
· Florida: Jacksonville
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Study of LHP588 in Subjects With P. Gingivalis-Positive Alzheimer's Disease
NCT06847321 ·
Phase: Phase 2 ·
Ages: 55 Years to 80 Years ·
Sex: All (male and female)
· Florida: Atlantis, Delray Beach, Fort Myers, Orlando
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Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986368, for the Treatment of Agitation in Participants With Alzheimer's Disease
NCT06808984 ·
Phase: Phase 2 ·
Ages: 55 Years to 90 Years ·
Sex: All (male and female)
· Florida: Daytona Beach, Maitland, Miami, Tampa
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University of Central Florida CereBank
NCT06876857 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: Female
· Florida: Orlando
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[18F]PI-2620 Phase 3 Histopathological Study
NCT05641688 ·
Phase: Phase 3 ·
Ages: 50 Years and older ·
Sex: All (male and female)
· Florida: Hialeah, Jacksonville, Lady Lake, Maitland