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A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors
NCT06270706 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: East Brunswick
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A Phase 1/1b Study of IAM1363 in HER2 Cancers
NCT06253871 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: New Brunswick
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A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Colorectal Cancer
NCT07659795 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: East Brunswick
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A Randomized Phase 2 Trial of Fruquintinib and TAS-102 as Compared to Fruquintinib in Patients With Refractory Advanced/Metastatic Colorectal Cancer
NCT06992258 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: New Brunswick
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A Study of ASP546C in Adults With Gastroesophageal Cancer, Pancreatic Cancer or Other Solid Tumors
NCT07488676 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Hackensack
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A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy
NCT06750094 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: East Brunswick
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A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
NCT06662786 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: East Brunswick, New Brunswick
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A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors
NCT04895709 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Hackensack
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A Study of BMS-986488 as Monotherapy and Combination Therapy in Participants With Advanced Malignant Tumors
NCT06764771 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Hackensack
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A Study of BMS-986490 With or Without Bevacizumab in Advanced Solid Tumors
NCT06730750 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Hackensack
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A Study of Botensilimab and Balstilimab for Colorectal Cancer With ctDNA+ After Surgery and Chemotherapy
NCT07227636 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Basking Ridge, Middletown, Montvale
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A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation
NCT06778863 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Hackensack
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A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation
NCT05877599 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: New Brunswick
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A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer
NCT06792695 ·
Phase: Phase 2 ·
Ages: 18 Years to 130 Years ·
Sex: All (male and female)
· New Jersey: Trenton
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A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements
NCT03093116 ·
Phase: Phase 1, Phase 2 ·
Ages: 12 Years and older ·
Sex: All (male and female)
· New Jersey: New Brunswick
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A Study of Response to Standard Treatment Before Surgery in People With Rectal Cancer
NCT06637462 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Middletown, Montvale
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A Study of Single Fraction Stereotactic Body Radiation Therapy (SBRT) Guided by Magnetic Resonance Imaging (MRI) in People With Liver Metastasis From Colorectal Cancer
NCT06130280 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Basking Ridge, Middletown, Montvale
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A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
NCT05253651 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Basking Ridge, Middletown, Montvale
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A Study of Tucatinib and Trastuzumab in People With Rectal Cancer
NCT05672524 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Basking Ridge, Middletown, Montvale
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A Study to Access Intravenous (IV) Telisotuzumab Adizutecan in Combination With IV Bevacizumab Compared to Standard of Care IV Bevacizumabin Combination With Oral Trifluridine and Tipiracil in Adult Participants With Refractory Metastatic Colorectal Cancer
NCT07525206 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: East Brunswick
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A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation
NCT06179160 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Hackensack
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A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors
NCT06004245 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: New Brunswick
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A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors
NCT07094204 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Hackensack
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A Study to Investigate ALE.P03 as Monotherapy in Adult Patients With Selected Advanced or Metastatic CLDN1+ Solid Tumors
NCT07169734 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Hackensack
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A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Efficacy of IDE574 Therapy in Adult Participants With Advanced Solid Tumors
NCT07540572 ·
Phase: Phase 1 ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female)
· New Jersey: East Brunswick
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A Trial to Evaluate the Safety and Activity of Fruquintinib in Minority Populations With Advanced, Previously Treated Colorectal Cancer
NCT06562543 ·
Phase: Phase 4 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Pennington
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Ascertainment of Families for Genetic Studies of Familial Lymphoproliferative Disorders
NCT00582621 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· New Jersey: Basking Ridge, Middletown
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CT-95 in Advanced Cancers Associated With Mesothelin Expression
NCT06756035 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Hackensack
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Changes in Reproductive and Sexual Health in People With Early Onset Colorectal Cancer
NCT04812912 ·
Phase: Not specified ·
Ages: 18 Years to 50 Years ·
Sex: All (male and female)
· New Jersey: Basking Ridge, Middletown, Montvale
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Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
NCT05334069 ·
Phase: Not specified ·
Ages: 40 Years to 75 Years ·
Sex: All (male and female)
· New Jersey: Englewood, Freehold, Hackettstown, Morristown
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Collection of Information to Better Understand Young Onset Colorectal Cancer
NCT04489238 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Basking Ridge, Middletown, Montvale
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Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
NCT05174169 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Berkeley Heights, Cape May Court House, Cherry Hill, Egg Harbor
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DPYD Pharmacogenomics and Fluoropyrimidine (FP) Dose-Adjustment
NCT07158164 ·
Phase: Phase 4 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Belleville, Elizabeth, Hamilton, Jersey City
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E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers
NCT05639972 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: New Brunswick
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E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers
NCT05686226 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: New Brunswick
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EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors
NCT07262619 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Morristown
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Evaluating Novel Therapies in ctDNA Positive GI Cancers
NCT05482516 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Hackensack
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FOLFIRI and Bevacizumab With or Without Pelareorep for Second-Line Treatment of Metastatic RAS-Mutated, Microsatellite-Stable Colorectal Cancer
NCT07446322 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Florham Park, New Brunswick
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Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps
NCT05080673 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 45 Years to 70 Years ·
Sex: All (male and female)
· New Jersey: Morristown
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KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors
NCT06026410 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: New Brunswick
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Microbiotic Product to Promote Microbiome Health and Improve Chemotherapy Delivery
NCT05296681 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Hamilton, Lakewood, Livingston, New Brunswick
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Minimal Residual Disease Assessment in Patients With Colorectal Cancer, the MiRDA-C Study
NCT04739072 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Camden
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Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer
NCT06205485 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Basking Ridge, Middletown, Montvale
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ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
NCT05059444 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: East Brunswick
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Phase 1/2 Dose Finding, Safety and PK Study in Advanced Refractory Solid Tumors
NCT07145255 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: East Brunswick
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Phase 2 Study of SR-8541A in Combination With Botensilimab and Balstilimab in Subjects With Refractory Metastatic Microsatellite Stable Colorectal Cancer (MSS-CRC)
NCT06589440 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Morristown
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Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer
NCT07228832 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: New Brunswick
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Researching the Effect of Exercise on Cancer
NCT04589468 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Basking Ridge, Middletown, Montvale
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SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
NCT03452774 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· New Jersey: New Brunswick
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Sequential TAS-OX Alternating With TAS-IRI Plus Bevacizumab for Late-Line Metastatic Colorectal Cancer
NCT05806931 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Elizabeth, Jersey City, Lakewood, Livingston
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Shield Post-Approval Study Protocol
NCT06880055 ·
Phase: Not specified ·
Ages: 45 Years to 81 Years ·
Sex: All (male and female)
· New Jersey: Clifton, Hackensack, Montclair, Ridgewood
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Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
NCT05489211 ·
Phase: Phase 2 ·
Ages: 18 Years to 130 Years ·
Sex: All (male and female)
· New Jersey: East Brunswick
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Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors
NCT04165772 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Basking Ridge, Middletown, Montvale
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Study of Pembrolizumab, Carboplatin, Paclitaxel, and Radiation for the Treatment of Early-Stage Anal Cancer
NCT06493019 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: New Brunswick
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Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
NCT06445062 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Morristown
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Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation
NCT06252649 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Mickleton
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Study of XmAb®819 in Subjects With Advanced Clear Cell Renal Cell Carcinoma
NCT05433142 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: New Brunswick
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Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
NCT05176483 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: East Brunswick, Hackensack
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TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers
NCT04485013 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: New Brunswick
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Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial
NCT05863195 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Basking Ridge, Middletown, Montvale
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Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, The ERASur Study
NCT05673148 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· New Jersey: Basking Ridge, Englewood, Middletown, Montvale
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The Radiation Oncology-Biology Integration Network (ROBIN) Molecular Characterization Trial (MCT) of Standard Short Course Radiotherapy for Rectal Cancer
NCT05943210 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 90 Years ·
Sex: All (male and female)
· New Jersey: New Brunswick