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A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
NCT07115329 ·
Phase: Phase 2 ·
Ages: 18 Years to 64 Years ·
Sex: All (male and female)
· Maryland: Rockville, Towson
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A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
NCT03887715 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Maryland: Baltimore, Glen Burnie
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A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)
NCT07076407 ·
Phase: Phase 3 ·
Ages: 18 Years to 74 Years ·
Sex: All (male and female)
· Maryland: Baltimore
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A Study of Brenipatide in Adult Participants With Major Depressive Disorder
NCT07412756 ·
Phase: Phase 3 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Maryland: Baltimore
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A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder
NCT07573176 ·
Phase: Phase 3 ·
Ages: 18 Years to 74 Years ·
Sex: All (male and female)
· Maryland: Baltimore
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A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
NCT06793397 ·
Phase: Phase 3 ·
Ages: 18 Years to 85 Years ·
Sex: All (male and female)
· Maryland: Baltimore
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A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
NCT04777357 ·
Phase: Phase 3 ·
Ages: 10 Years to 17 Years ·
Sex: All (male and female)
· Maryland: Baltimore
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A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
NCT06524830 ·
Phase: Phase 2 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Maryland: Baltimore, Rockville
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A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
NCT07621237 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Maryland: Rockville
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A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
NCT07300969 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Maryland: Gaithersburg
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A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder
NCT07227454 ·
Phase: Phase 3 ·
Ages: 12 Years to 17 Years ·
Sex: All (male and female)
· Maryland: Baltimore
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ALTO-100 in Bipolar Disorder With Depression (BD-D)
NCT06656416 ·
Phase: Phase 2 ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Maryland: Baltimore, Bel Air, Gaithersburg
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ALTO-207 in Adults With Treatment-resistant Depression (TRD)
NCT07553637 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Maryland: Annapolis, Pikesville
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Advanced Prediction of Respiratory Depression Episode Using the Linshom Continuous Predictive Respiratory Sensor
NCT06744790 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Maryland: Baltimore
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Allopregnanolone and Dynamic GABA-A Receptor Plasticity in Selective Serotonin Reuptake Inhibitor Responsive Premenstrual Dysphoric Disorder
NCT06704594 ·
Phase: Phase 4 ·
Ages: 18 Years to 50 Years ·
Sex: Female
· Maryland: Baltimore
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Being Safe, Healthy, And Positively Empowered (BSHAPE) Intervention Study
NCT07227337 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: Female
· Maryland: Baltimore
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CAPABLE Transplant
NCT06326905 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female)
· Maryland: Baltimore
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CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms
NCT05663034 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Maryland: Bethesda
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Change in Social Media Use and Well-being Among College Students Receiving a Two-week Exercise or Mindfulness Intervention
NCT07097545 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Maryland: Baltimore
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Characterization and Treatment of Adolescent Depression
NCT03388606 ·
Phase: Not specified ·
Ages: 11 Years to 25 Years ·
Sex: All (male and female)
· Maryland: Bethesda
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Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol
NCT07484217 ·
Phase: Phase 3 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Maryland: Pikesville
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Clinical Trial on Agitation in Alzheimer's Dementia
NCT05543681 ·
Phase: Phase 2 ·
Ages: 60 Years and older ·
Sex: All (male and female)
· Maryland: Baltimore, Clinton, Olney
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Defining Neurobiological Links Between Substance Use and Mental Illness
NCT05538910 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 60 Years ·
Sex: All (male and female)
· Maryland: Baltimore
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E-Mindfulness Approaches for Living After Breast Cancer
NCT06748222 ·
Phase: Phase 3 ·
Ages: 18 Years to 50 Years ·
Sex: All (male and female)
· Maryland: Baltimore, Bel Air, Clinton, Columbia
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Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers
NCT00024635 ·
Phase: Not specified ·
Ages: 3 Years to 99 Years ·
Sex: All (male and female)
· Maryland: Bethesda
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Glucose Variability and Cognition in Prediabetes
NCT04201600 ·
Phase: Not specified ·
Ages: 50 Years and older ·
Sex: All (male and female)
· Maryland: Baltimore
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Identification and Validation of Epigenetic Biomarkers of PMDD
NCT06771583 ·
Phase: Not specified ·
Ages: 18 Years to 50 Years ·
Sex: Female
· Maryland: Baltimore
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Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
NCT06511908 ·
Phase: Phase 2 ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Maryland: Bethesda
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Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
NCT06966401 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Maryland: Gaithersburg
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Long-term Observation of Participants With Mood Disorders
NCT04877977 ·
Phase: Not specified ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female)
· Maryland: Bethesda
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Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression
NCT03973268 ·
Phase: Phase 1 ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Maryland: Bethesda
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Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients
NCT06372964 ·
Phase: Phase 3 ·
Ages: 10 Years to 17 Years ·
Sex: All (male and female)
· Maryland: Baltimore
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NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
NCT06963021 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Maryland: Gaithersburg
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NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder
NCT05669703 ·
Phase: Not specified ·
Ages: 8 Years to 70 Years ·
Sex: All (male and female)
· Maryland: Bethesda
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Natural History of Depression, Bipolar Disorder and Suicide Risk
NCT06462196 ·
Phase: Not specified ·
Ages: 18 Years to 120 Years ·
Sex: All (male and female)
· Maryland: Bethesda
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Neurobiology of Suicide
NCT02543983 ·
Phase: Phase 2 ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Maryland: Bethesda
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Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
NCT03065335 ·
Phase: Phase 1 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Maryland: Bethesda
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PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)
NCT04582916 ·
Phase: Phase 1 ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Maryland: Bethesda
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Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease
NCT04123314 ·
Phase: Early Phase 1 ·
Ages: 18 Years to 85 Years ·
Sex: All (male and female)
· Maryland: Baltimore
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Psilocybin in Chronic Low Back Pain and Depression
NCT06355414 ·
Phase: Phase 1 ·
Ages: 21 Years to 80 Years ·
Sex: All (male and female)
· Maryland: Baltimore
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RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
NCT07002034 ·
Phase: Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female)
· Maryland: Rockville, Towson
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Strength and Pain-Coping Through Resilience and Knowledge
NCT07228520 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 50 Years and older ·
Sex: All (male and female)
· Maryland: Baltimore
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Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders
NCT00018057 ·
Phase: Phase 2 ·
Ages: 8 Years to 65 Years ·
Sex: All (male and female)
· Maryland: Bethesda, College Park
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VR-PMR for Post-Burn Symptoms
NCT07317271 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Maryland: Baltimore
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[18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET
NCT05703685 ·
Phase: Phase 1 ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Maryland: Bethesda