Clinical trials recruiting for Depression
1,463
Recruiting trials
50
US states with sites
78
Countries
27%
Accept healthy volunteers
Phase breakdown
Drugs and treatments being studied
| Intervention | Trials |
|---|---|
| Ketamine | 21 |
| Psilocybin | 19 |
| Ketamine Hydrochloride | 10 |
| Fluoxetine | 8 |
| Escitalopram | 7 |
| Sertraline | 6 |
| Esketamine | 5 |
| NBI-1065845 | 5 |
| Azetukalner | 3 |
| Brexpiprazole | 3 |
| Bupropion | 3 |
| Lithium | 3 |
Where trials are recruiting (top US states)
| State | Recruiting trials |
|---|---|
| California | 116 |
| New York | 111 |
| Massachusetts | 100 |
| Texas | 96 |
| Florida | 72 |
| Pennsylvania | 70 |
| Ohio | 53 |
| Georgia | 47 |
| Illinois | 46 |
| Maryland | 45 |
| North Carolina | 41 |
| Missouri | 37 |
Top cities
New York, New York 80Boston, Massachusetts 70Houston, Texas 45Chicago, Illinois 38Atlanta, Georgia 37Los Angeles, California 33Miami, Florida 33Philadelphia, Pennsylvania 33Austin, Texas 28San Diego, California 27
Self-screener
Recruiting trials
- "Erectile Function After PCI in MI and Non-MI Patients"
- "Machine Learning Analysis of Lingual Colorimetry and MADRS Anxiety-Depression Score in Acupuncture Patients"
- 40 Hz Light Neurostimulation for Patients With Depression (FELIX)
- 5-HTP and Creatine for Depression R33 Phase
- 7T Amygdala and Citalopram Study
- A Behavioral mHealth Intervention for People With HIV With Anxiety and Depression
- A Cohort Study of Disease Prediction Model for High-risk Population With Bipolar Disorder
- A Comparative Effectiveness Study of PTSD Treatments Among Sexual and Gender Minority Populations
- A Comparison of Remimazolam Besylate and Propofol Sedation in Patients Undergoing Colonoscopic Polypectomy
- A Comparison of Two Psychotherapy Programs in Persistently Depressed Treatment-Resistant Inpatients
- A Computerized Depression Intervention in Veterans
- A Digital Intervention for Post-Stroke Depression and Executive Dysfunction
- A Digitally Assisted Risk Reduction Platform for Youth at High Risk for Suicide
- A Just-in-time Adaptive Intervention for Suicide Safety Planning in Adolescents
- A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults With Depression
- A Long-Term Study of Patient-Reported Changes in Postpartum Depression Symptoms in People Starting Zuranolone
- A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and Anxiety
- A Mental Health Services Engagement Program for Racial and Ethnic Minority Young Adults
- A Metacognitive Group Therapy of Depression and Anxiety in Youth With Autism
- A Mobile Application for Early Detection and Symptoms Trajectories of Postpartum Depression Using Ecological Momentary Assessment (EMA)
- A Multicenter Study Based on Multi-omics Analysis to Predict the Early Prognosis and Recurrence Risk of Acute Ischemic Stroke
- A New Clinical Model for the Engagement of Latinx Youth With Suicidal Behavior
- A New Intervention to Improve Function in Veterans With Anxiety and Depression
- A Novel Blood Test as a Biomarker in Mental Health
- A Novel Individualized Connectome-guided Approach for Precision Intermittent Theta Burst Stimulation for Depression
- A Patient Activation Approach to Implementing Depression Treatment in Cardiac Patients
- A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
- A Phase 2a Study to Evaluate the Safety and Tolerability of GM-2505 in Patients With MDD
- A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
- A Pilot Study of Synbiotics in Adults With Depressive Symptoms
- A Pilot Study to Assess the Impact of Breath Awareness Using Pyramid on Symptoms of Anxiety and Depression in People with T2DM
- A Pilot Study to Examine the Efficacy of Internet-Delivered Skills Training in Affective and Interpersonal Regulation (i-STAIR) for Individuals With Adverse Childhood Experiences and Subsyndromal Depression
- A Precision Medicine Approach to Target Engagement for Emotion Regulation
- A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD
- A Problem-Solving Intervention for Women With Suicidal Ideation During Postnatal Period in Pakistan
- A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
- A Randomized Clinical Trial Comparing Active Versus Sham T-PEMF Headband Treatment for Depression
- A Randomized Neuroimaging Trial of Psilocybin in Depression
- A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression
- A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)
- A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder
- A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)
- A Remotely Delivered Tai Chi/Qigong Intervention for Older People Living With HIV
- A Study of Brenipatide in Adult Participants With Major Depressive Disorder
- A Study of Brief Behavioral Activation for the Treatment of Depression in Older Adult Cancer Survivors
- A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant Depression
- A Study of Home-use Brain Stimulation to Treat Bipolar Depression
- A Study of MI078 for Postpartum Depression
- A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder
- A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
- A Study of a One-Time Counseling Session to Help Reduce Depression, Anxiety, and Distress in People With Breast Cancer
- A Study of a Test for Postpartum Depression at Home
- A Study to Assess Adverse Events and Change in Disease Activity of Oral Icalcaprant in Adult Participants With Bipolar I or II Disorder
- A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
- A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder
- A Study to Assess Effectiveness and Efficiency of VNS Therapy in Patients With Difficult to Treat Depression.
- A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
- A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
- A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
- A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
- A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor
- A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder
- A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
- A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms
- A Study to Evaluate the Efficacy, Safety, and Pharmacokinetic Characteristics of (R)-Ketamine Hydrochloride Nasal Spray in Patients With Depression and Acute Suicidal Ideation or Behavior
- A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- A Study to Learn More About How Zuranolone Affects Postpartum Depression Symptoms in Participants Who Took it Within 1 Year After The End of Their Pregnancy
- A Trial of Dextromethorphan and Bupropion Sustained-Release Tablets in Patients With Major Depressive Disorder
- A Trial to Investigate the Accuracy of a Wearable Device in Collecting Data Related to Perimenopausal Symptoms in Women
- ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
- ACT Together: Implementing a Web-Based Program With Brief Coaching for Parents of Children With Disabilities in Pediatric Outpatient Clinics
- ACT for Individuals With MNCD and Their Care Partners
- ACT for Mental Health in Neurological Disorders
- ACT_for Alcohol Use Disorder and Depression
- AI-Based Personalized Exercise Prescription Through Mobile Health on Physical Activity and Health Outcomes in Older Adults: A Feasibility Study
- AI-Guided CBT for Depression and Anxiety
- ALTO-100 in Bipolar Disorder With Depression (BD-D)
- ALTO-207 in Adults With Treatment-resistant Depression (TRD)
- AR Health Education Video for Postoperative Breast Cancer Patients
- ASHA Bangladesh--An Integrated Intervention to Address Poverty and Depression
- ATLAS-1: Advanced Trial for Longitudinal Assessment in Salma 1
- Accelerated High-Dose tDCS for Depression
- Accelerated Intermittent Theta Burst Stimulation for Adolescent and Young Adult Depression With Elevated Suicide Risk
- Accelerated Intermittent Theta Burst in Treatment-Naive Adolescents
- Accelerated Intermittent Theta-Burst Stimulation Ameliorate Major Depressive Disorder by Regulating CAMKII Pathway
- Accelerated Neuromodulation of Anterior Cingulate Cortex for Depression
- Accelerated TMS for Perinatal Depression
- Accelerated TMS for Treatment-Resistant ECT
- Accelerated Treatment of Depressive Patients With tDCS
- Accelerated Versus Standard Intermittent Theta Burst Stimulation for Major Depressive Disorder
- Accelerated iTBS for Depression: Monitoring Brain Hemodynamics With Simultaneous iTBS/fNIRS
- Accelerated iTBS for Major Depression
- Accelerated iTBS for Post Partum Depression
- Accelerated rTMS for Substance Use Disorder and Depression
- Accelerated rTMS vs. Sham for Stroke Apathy
- Accelerated vs. Conventional Theta Burst Stimulation for Late-life Depression
- Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and Suicidality
- Acceptability and Feasibility of Work-Oriented Social-Cognitive Skills Training for Veterans With Serious Mental Illness
- Acceptability and Feasibility of an In-person 8-week Mindfulness-Based Cognitive Therapy Program Among Undergraduates
- Acceptance and Commitment Therapy for Adolescents and Young Adults With Sickle Cell Disease
Related conditions
Trials recruiting for Depression often also study these conditions. Each links to its own recruiting-trial list.
Anxiety 1237Major depressive disorder 166Bipolar disorder 212Treatment-resistant depression 50Depression, Anxiety 49Depressive Disorder 48Schizophrenia 386Anxiety Disorders 75Depressive Disorder, Major 33Suicidal Ideation 29
Common questions
Are these trials free to join?
Study-related care in a clinical trial is usually provided at no cost to participants, and some trials reimburse travel. Costs vary by study - the trial team will explain what is and is not covered. Confirm this directly with them.
How do I know if I am eligible for Depression trials?
Each trial lists inclusion and exclusion criteria. The screener above checks stated age and sex only. The full eligibility (your medical history, current medications, test results) is assessed by the study team. Open any trial to read its criteria, then contact the site.
Is this list complete?
No. For the full list, search ClinicalTrials.gov.