Depression trials recruiting in Massachusetts

All Depression trials nationally

Cities in Massachusetts

Recruiting trials in Massachusetts

• A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults With Depression
  NCT06597695 · Phase: Phase 1, Phase 2 · Ages: 18 Years to 64 Years · Sex: All (male and female) · Massachusetts: Chelsea
• A Long-Term Study of Patient-Reported Changes in Postpartum Depression Symptoms in People Starting Zuranolone
  NCT07398469 · Phase: Not specified · Ages: 18 Years and older · Sex: Female · Massachusetts: Cambridge
• A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
  NCT07115329 · Phase: Phase 2 · Ages: 18 Years to 64 Years · Sex: All (male and female) · Massachusetts: Worcester
• A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
  NCT07592689 · Phase: Phase 3 · Ages: 18 Years to 74 Years · Sex: All (male and female) · Massachusetts: Boston, Worcester
• A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
  NCT03887715 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · Massachusetts: Boston
• A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder
  NCT06775379 · Phase: Phase 3 · Ages: 18 Years to 74 Years · Sex: All (male and female) · Massachusetts: Boston, Springfield
• A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)
  NCT07076407 · Phase: Phase 3 · Ages: 18 Years to 74 Years · Sex: All (male and female) · Massachusetts: Boston, Methuen, Watertown, Worcester
• A Study of Brenipatide in Adult Participants With Major Depressive Disorder
  NCT07412756 · Phase: Phase 3 · Ages: 18 Years to 75 Years · Sex: All (male and female) · Massachusetts: Boston, Foxborough, Watertown
• A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder
  NCT07573176 · Phase: Phase 3 · Ages: 18 Years to 74 Years · Sex: All (male and female) · Massachusetts: Boston, Watertown
• A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
  NCT06524830 · Phase: Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · Massachusetts: Springfield, Watertown
• A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
  NCT07621237 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · Massachusetts: Methuen
• A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
  NCT07610473 · Phase: Phase 2 · Ages: 18 Years to 75 Years · Sex: All (male and female) · Massachusetts: Boston
• A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
  NCT07300969 · Phase: Phase 2 · Ages: 18 Years to 75 Years · Sex: All (male and female) · Massachusetts: Watertown
• A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder
  NCT07227454 · Phase: Phase 3 · Ages: 12 Years to 17 Years · Sex: All (male and female) · Massachusetts: Boston
• A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
  NCT07065240 · Phase: Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · Massachusetts: Boston, Russells Mills
• A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms
  NCT06223880 · Phase: Phase 4 · Ages: 18 Years to 65 Years · Sex: All (male and female) · Massachusetts: Boston
• ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
  NCT07284667 · Phase: Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · Massachusetts: Watertown, Worcester
• ALTO-207 in Adults With Treatment-resistant Depression (TRD)
  NCT07553637 · Phase: Phase 2 · Ages: 18 Years to 75 Years · Sex: All (male and female) · Massachusetts: Worcester
• Accelerated TMS for Perinatal Depression
  NCT06968390 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 55 Years · Sex: Female · Massachusetts: Boston
• Assessing the Impact of Cannabidiol for Anxiety and Depression in Bipolar Disorder
  NCT05457465 · Phase: Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · Massachusetts: Belmont
• BTL-699-2 and HPM-6000UF Devices for the Improvement of Depressive Symptoms and Sexual Function Among Perimenopausal and Postmenopausal Women
  NCT07413705 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years and older · Sex: Female · Massachusetts: Wellesley
• Behavioral Health Program for Short-Stay Nursing Facility Residents & Care Partners
  NCT07220486 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · Massachusetts: Boston
• Beyond Monoamines: The Role of the Nociceptin/Orphanin FQ Receptor in Major Depression
  NCT05630963 · Phase: Not specified · Ages: 18 Years to 45 Years · Sex: All (male and female) · Massachusetts: Belmont
• Brain Connectivity in Depression
  NCT03276793 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · Massachusetts: Boston
• Brain Stimulation for Severe Depression
  NCT05393622 · Phase: Not applicable (e.g. observational or device study) · Ages: 21 Years to 80 Years · Sex: All (male and female) · Massachusetts: Boston
• Bridge to Belonging: Peer Led Intervention to Reduce Loneliness and Depression Among Older Gay and Bisexual Men
  NCT07762066 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years and older · Sex: All (male and female) · Massachusetts: Boston
• Building Connections
  NCT07091032 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 75 Years · Sex: All (male and female) · Massachusetts: Boston
• Buspirone and Melatonin for Depression Following Traumatic Brain Injury
  NCT04400266 · Phase: Phase 4 · Ages: 18 Years to 64 Years · Sex: All (male and female) · Massachusetts: Boston, Charlestown
• Cannabidiol for Reduction of Brain Neuroinflammation
  NCT05066308 · Phase: Phase 2 · Ages: 18 Years to 75 Years · Sex: All (male and female) · Massachusetts: Boston
• Cannabis, Linked Emotions, and Adolescent Risk Study
  NCT06576076 · Phase: Not applicable (e.g. observational or device study) · Ages: 12 Years to 18 Years · Sex: All (male and female) · Massachusetts: Boston
• Changing Lives and Changing Outcomes-9 at Worcester Recovery Center and Hospital
  NCT07359157 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · Massachusetts: Worcester
• Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol
  NCT07484217 · Phase: Phase 3 · Ages: 18 Years to 65 Years · Sex: All (male and female) · Massachusetts: Springfield
• Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression
  NCT07563868 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · Massachusetts: Boston
• Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab
  NCT06136546 · Phase: Phase 2 · Ages: 25 Years to 50 Years · Sex: All (male and female) · Massachusetts: Boston
• Comparing the Efficacy of Heated Yoga and Sauna as a Treatment for Depression
  NCT07082998 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · Massachusetts: Boston
• Deep Brain Stimulation of Treatment-Resistant Bipolar Depression
  NCT06599099 · Phase: Not applicable (e.g. observational or device study) · Ages: 22 Years to 64 Years · Sex: All (male and female) · Massachusetts: Boston
• Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness
  NCT05962879 · Phase: Not applicable (e.g. observational or device study) · Ages: 14 Years to 19 Years · Sex: All (male and female) · Massachusetts: Boston
• E-Mindfulness Approaches for Living After Breast Cancer
  NCT06748222 · Phase: Phase 3 · Ages: 18 Years to 50 Years · Sex: All (male and female) · Massachusetts: Beverly, Boston, Burlington, Gloucester
• Early Life Stress and Depression: Molecular and Functional Imaging
  NCT04713722 · Phase: Not specified · Ages: 20 Years to 32 Years · Sex: Female · Massachusetts: Belmont
• Effects of Intranasal Oxytocin in Patients With Arginine-vasopressin Deficiency
  NCT04789148 · Phase: Phase 1 · Ages: 18 Years and older · Sex: All (male and female) · Massachusetts: Boston
• Efficacy and Safety of Magnesium Vitamin B6 in First Episode Bipolar Disorder
  NCT05837104 · Phase: Phase 2 · Ages: 18 Years to 50 Years · Sex: All (male and female) · Massachusetts: Belmont
• Expressive Writing on Minority Stressors Among Sexual Minority Veterans
  NCT05897021 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · Massachusetts: Boston
• Facilitated Transitions From Postpartum to Primary Care Coordination for People With Chronic Conditions
  NCT06557005 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: Female · Massachusetts: Boston
• Foundational Programs to Combat Clinician Stress
  NCT07220421 · Phase: Not applicable (e.g. observational or device study) · Ages: 25 Years to 70 Years · Sex: All (male and female) · Massachusetts: Boston
• Home-Based tDCS Treatment Of Major Depressive Disorder
  NCT06976697 · Phase: Not applicable (e.g. observational or device study) · Ages: 22 Years to 70 Years · Sex: All (male and female) · Massachusetts: Boston
• Implementing Depression and Adherence Treatment
  NCT07032363 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · Massachusetts: Boston
• Integrative Mindfulness-Based Predictive Approach for Chronic Low Back Pain Treatment
  NCT06106191 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · Massachusetts: Boston
• Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression
  NCT05450432 · Phase: Phase 4 · Ages: 18 Years to 70 Years · Sex: All (male and female) · Massachusetts: Boston
• Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
  NCT06966401 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · Massachusetts: Boston, Watertown
• Mechanisms Of Orbitofrontal Stimulation in Depression
  NCT07230990 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · Massachusetts: Boston
• Mind-body Resilience Program for Cardiac Arrest Survivors and Their Caregivers: Recovering Together After Cardiac Arrest
  NCT07143357 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · Massachusetts: Boston
• Mindfulness-Based fMRI Neurofeedback for Depression
  NCT05617495 · Phase: Not applicable (e.g. observational or device study) · Ages: 13 Years to 18 Years · Sex: All (male and female) · Massachusetts: Boston
• Mindfulness-based Cognitive Therapy vs the Health Enhancement Program for Chronic Pain and Depression; The Quiet Focus Study
  NCT07118722 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years to 120 Years · Sex: All (male and female) · Massachusetts: Boston
• Modulating Exercise Dosage to Improve Concussion Recovery
  NCT05434130 · Phase: Phase 1, Phase 2 · Ages: 13 Years to 18 Years · Sex: All (male and female) · Massachusetts: Boston, Cambridge
• NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
  NCT06911112 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · Massachusetts: Boston
• Neural Correlates of Stress and Perceived Control in Adolescent Depression
  NCT04788524 · Phase: Not applicable (e.g. observational or device study) · Ages: 14 Years to 18 Years · Sex: Female · Massachusetts: Belmont
• Neural Mechanisms of Family-Focused Treatment for Youth Depression
  NCT06289010 · Phase: Not applicable (e.g. observational or device study) · Ages: 7 Years to 12 Years · Sex: All (male and female) · Massachusetts: Boston, Charlestown
• Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV
  NCT05570812 · Phase: Phase 2 · Ages: 18 Years to 85 Years · Sex: All (male and female) · Massachusetts: Boston
• Observational Study of THC Concentrations in Acute Cannabis-induced CNS Depression
  NCT06017622 · Phase: Not specified · Ages: No age limits stated · Sex: All (male and female) · Massachusetts: Worcester
• One-Day cTBS Over the Precuneus
  NCT07758010 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · Massachusetts: Belmont
• Pathways to Perinatal Mental Health Equity
  NCT06790641 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 70 Years · Sex: All (male and female) · Massachusetts: Shrewsbury
• Peripheral Neuroimmune Mechanisms of Hyperthermia
  NCT05366270 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · Massachusetts: Boston
• Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Pharmacological Manipulation
  NCT05232032 · Phase: Phase 2 · Ages: 18 Years to 45 Years · Sex: All (male and female) · Massachusetts: Belmont
• Pharmacologic Augmentation of TMS for Depression With D-serine
  NCT06876129 · Phase: Phase 1 · Ages: 18 Years to 80 Years · Sex: All (male and female) · Massachusetts: Belmont
• Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
  NCT06559306 · Phase: Phase 3 · Ages: 18 Years to 74 Years · Sex: All (male and female) · Massachusetts: Boston, Watertown
• Pilot Study of a Behavioral Program for Resident Depression in Skilled Nursing Facilities
  NCT07655232 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · Massachusetts: Boston
• Preventing Depression of Chinese American Adolescents by RRE
  NCT05921201 · Phase: Not applicable (e.g. observational or device study) · Ages: 14 Years to 18 Years · Sex: All (male and female) · Massachusetts: Boston
• RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
  NCT07002034 · Phase: Phase 2 · Ages: 18 Years to 80 Years · Sex: All (male and female) · Massachusetts: Boston, Worcester
• REVEAL Study - Diagnostic Testing for PTSD Using the Senseye Diagnostic Tool
  NCT07280065 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · Massachusetts: Boston
• RISE Versus Advocacy-based Enhanced Care as Usual for Patients Experiencing IPV
  NCT06906302 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · Massachusetts: Boston
• Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa
  NCT05624931 · Phase: Not applicable (e.g. observational or device study) · Ages: 15 Years and older · Sex: Female · Massachusetts: Boston
• Researching Heat and Yoga for Mood Enhancement
  NCT06094088 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · Massachusetts: Cambridge
• SAINT in Postpartum Depression (PPD)
  NCT07210255 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 45 Years · Sex: Female · Massachusetts: Worcester
• Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness
  NCT06376734 · Phase: Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · Massachusetts: Boston
• Self-Help Cognitive Processing Therapy (CPT)/Women Veterans Network (WoVeN) Study
  NCT07250061 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: Female · Massachusetts: Boston
• Social Needs Screening and Chronic Diseases Study (WE CARE)
  NCT06903897 · Phase: Not applicable (e.g. observational or device study) · Ages: No age limits stated · Sex: All (male and female) · Massachusetts: Worcester
• Stress Dynamics and Familial Risk for Depression in Female Adolescents
  NCT06816329 · Phase: Not applicable (e.g. observational or device study) · Ages: 13 Years to 15 Years · Sex: Female · Massachusetts: Belmont
• Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)
  NCT06633016 · Phase: Phase 2 · Ages: 18 Years to 65 Years · Sex: All (male and female) · Massachusetts: Boston, Watertown
• Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder
  NCT05850689 · Phase: Phase 3 · Ages: 18 Years to 65 Years · Sex: All (male and female) · Massachusetts: Methuen
• Study on Allopregnanolone and Depression in Women Across the Menopause Transition
  NCT06238700 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years to 60 Years · Sex: Female · Massachusetts: Boston
• Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
  NCT06786624 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · Massachusetts: Boston, Watertown
• Synaptic Mechanisms of Continuous Theta Burst Stimulation in Depression
  NCT07560878 · Phase: Early Phase 1 · Ages: 18 Years and older · Sex: All (male and female) · Massachusetts: Belmont
• TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age
  NCT07048574 · Phase: Not specified · Ages: 18 Months to 11 Years · Sex: All (male and female) · Massachusetts: Boston
• Targeting Specific Brain Networks to Treat Specific Symptoms in Depression
  NCT05523817 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · Massachusetts: Boston
• Teenthrive 2: Treatments for Improving Mood in Teens
  NCT07475845 · Phase: Not applicable (e.g. observational or device study) · Ages: 12 Years to 18 Years · Sex: All (male and female) · Massachusetts: Boston
• Telemedicine-Delivered Unified Protocol for Cognitive Behavioral Therapy for Anxiety and Depression
  NCT05734313 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 64 Years · Sex: All (male and female) · Massachusetts: Boston
• Testing "Doula Link", a Multi-Component Intervention to Improve Perinatal Mental Health
  NCT07217561 · Phase: Not applicable (e.g. observational or device study) · Ages: No age limits stated · Sex: All (male and female) · Massachusetts: Boston
• The Effect of PROSE or Scleral Lenses on Mental Health
  NCT07195721 · Phase: Not specified · Ages: No age limits stated · Sex: All (male and female) · Massachusetts: Needham
• The Effects of Lumateperone on Obesity and Physiologic Aging and Their Association With Antidepressant Response in Bipolar Depression
  NCT07699445 · Phase: Phase 4 · Ages: 18 Years to 65 Years · Sex: All (male and female) · Massachusetts: Boston
• The Effects of Psilocybin on Self-Focus and Self-Related Processing in Major Depressive Disorder
  NCT06247839 · Phase: Phase 3 · Ages: 18 Years to 55 Years · Sex: All (male and female) · Massachusetts: Charlestown
• The Medically Tailored Groceries and Mental Health Study
  NCT07779707 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · Massachusetts: Worcester
• Therapy Dog Visits for Patients Hospitalized With Traumatic Injuries
  NCT06812247 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · Massachusetts: Boston
• Time Restricted Eating (TRE) in Bipolar Disorder
  NCT07211217 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · Massachusetts: Boston
• Training in Evidence-based Treatments in Psycho-Oncology
  NCT05674357 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · Massachusetts: Boston
• Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations
  NCT04296604 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · Massachusetts: Boston
• Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression - R33
  NCT05573074 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · Massachusetts: Boston
• Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
  NCT06423430 · Phase: Not applicable (e.g. observational or device study) · Ages: 22 Years to 70 Years · Sex: All (male and female) · Massachusetts: Boston
• Triage Survey for Psychiatry Research Eligibility
  NCT05800925 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · Massachusetts: Boston, Watertown
• Using Machine Learning to Optimize User Engagement and Clinical Response to Digital Mental Health Interventions
  NCT05567640 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · Massachusetts: Boston
• Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
  NCT06547489 · Phase: Phase 2 · Ages: 18 Years to 64 Years · Sex: All (male and female) · Massachusetts: Boston, Russells Mills