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A Clinical Study to Evaluate the Safety and Efficacy of ETX101 in Infants and Children With SCN1A-Positive Dravet Syndrome
NCT05419492 ·
Phase: Phase 1, Phase 2 ·
Ages: 6 Months to 17 Years ·
Sex: All (male and female)
· California: San Francisco
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A Clinical Trial of Elsunersen in Pediatric SCN2A-DEE to Assess Efficacy and Safety
NCT07019922 ·
Phase: Phase 3 ·
Ages: 1 Day to 18 Years ·
Sex: All (male and female)
· California: San Diego
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A Double-blind Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen in Patients With Dravet Syndrome
NCT06872125 ·
Phase: Phase 3 ·
Ages: 2 Years to 17 Years ·
Sex: All (male and female)
· California: Los Angeles, Orange, San Francisco
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A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy
NCT07227857 ·
Phase: Phase 1, Phase 2 ·
Ages: 2 Years to 12 Years ·
Sex: All (male and female)
· California: Orange
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A Phase 1/2 Study of NRTX-1001 Neuronal Cell Therapy in Drug-Resistant Bilateral Mesial Temporal Lobe Epilepsy (MTLE)
NCT06422923 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· California: Los Angeles, Orange, Palo Alto, San Diego
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A Phase 3, Placebo-Controlled Study to Investigate LP352 in Children and Adults With Dravet Syndrome (DS)
NCT06660394 ·
Phase: Phase 3 ·
Ages: 2 Years to 65 Years ·
Sex: All (male and female)
· California: Los Angeles, Palo Alto, San Francisco
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A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)
NCT05716100 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· California: Downey, Los Angeles, Orange
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A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound Neuromodulation in Patients With Drug-resistant Epilepsy
NCT06388707 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· California: Palo Alto
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A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome
NCT04462770 ·
Phase: Phase 3 ·
Ages: 2 Years and older ·
Sex: All (male and female)
· California: Los Angeles, Orange, San Francisco
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A Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy
NCT06132893 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· California: La Jolla, Los Angeles, Palo Alto, Pasadena
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A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures
NCT05667142 ·
Phase: Phase 3 ·
Ages: 12 Years and older ·
Sex: All (male and female)
· California: Los Angeles, Orange, Sacramento
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A Study to Prevent Infantile Spasms Relapse
NCT06819670 ·
Phase: Phase 2 ·
Ages: 2 Months to 18 Months ·
Sex: All (male and female)
· California: Los Angeles
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AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy
NCT06063850 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· California: Palo Alto
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An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome
NCT05066217 ·
Phase: Phase 3 ·
Ages: 2 Years to 55 Years ·
Sex: All (male and female)
· California: Orange
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Brain Development Research Program
NCT00305305 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· California: San Francisco
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Cognitive and Electrophysiological Assessment of Non-Invasive Temporally-Interfering Electric Fields Stimulation (TIEFS)
NCT07663578 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· California: Sacramento
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Congenital Muscle Disease Study of Patient and Family Reported Medical Information
NCT01403402 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· California: Lakewood
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Diagnosing Epilepsy To EffeCT Change
NCT07110337 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· California: Irvine, Palo Alto
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Diagnosing Epilepsy To EffeCT Change Long-Term Follow-Up
NCT07110454 ·
Phase: Not specified ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· California: Palo Alto
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Epilepsy Journey-An Executive Functioning Intervention for Teens With Epilepsy
NCT06608966 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 13 Years to 17 Years ·
Sex: All (male and female)
· California: Orange
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Epilepsy Learning Healthcare System (ELHS)
NCT06265103 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· California: Los Angeles
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Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults
NCT05219617 ·
Phase: Phase 3 ·
Ages: 4 Years to 55 Years ·
Sex: All (male and female)
· California: Palo Alto
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Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in Humans
NCT05996900 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· California: Stanford
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Model-based Electrical Brain Stimulation
NCT05327387 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· California: Los Angeles, San Francisco
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Non-Invasive Low Intensity Focused Ultrasound Stimulation for Drug-Resistant Epilepsy
NCT07680842 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 21 Years to 65 Years ·
Sex: All (male and female)
· California: San Francisco
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North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)
NCT01694940 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· California: San Diego, Stanford
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Novel Multimodal Neural, Physiological, and Behavioral Sensing and Machine Learning for Mental States
NCT07110688 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· California: Downey, Los Angeles
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Prospective Natural History Study of POLG Disease
NCT07775872 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· California: San Diego
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STXBP1 and SYNGAP1 Related Disorders Natural History Study
NCT06555965 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· California: Palo Alto
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Sleep Architecture & Cognition in Focal Epilepsy
NCT05794295 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 40 Years ·
Sex: All (male and female)
· California: Sacramento
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Spatial Scene Recognition Memory in Epilepsy Surgery
NCT07580183 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 55 Years ·
Sex: All (male and female)
· California: Sacramento
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Stopping TSC Onset and Progression 2B: Sirolimus TSC Epilepsy Prevention Study
NCT05104983 ·
Phase: Phase 2 ·
Ages: 1 Day to 6 Months ·
Sex: All (male and female)
· California: Los Angeles, Palo Alto
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Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1
NCT07563881 ·
Phase: Phase 3 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· California: Palmdale
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Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (EPIC (EPIlepsy Cell Therapy))
NCT05135091 ·
Phase: Phase 3 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· California: Los Angeles, Orange, Palo Alto, Sacramento
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Treatment of Refractory Infantile Spasms With Fenfluramine
NCT04289467 ·
Phase: Phase 2 ·
Ages: 12 Months to 36 Months ·
Sex: All (male and female)
· California: Los Angeles, Orange
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Understanding Ketamine's Dissociative Effects (KD Study)
NCT04861051 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· California: Palo Alto
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Understanding Prefrontal and Medial Temporal Neuronal Responses to Algorithmic Cognitive Variables in Epilepsy Patients
NCT05283811 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 10 Years to 64 Years ·
Sex: All (male and female)
· California: Los Angeles