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A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders
NCT06092346 ·
Phase: Not specified ·
Ages: 1 Month to 100 Years ·
Sex: All (male and female)
· Maryland: Bethesda
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A Phase 3, Placebo-Controlled Study to Investigate LP352 in Children and Adults With Dravet Syndrome (DS)
NCT06660394 ·
Phase: Phase 3 ·
Ages: 2 Years to 65 Years ·
Sex: All (male and female)
· Maryland: Bethesda
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A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)
NCT05716100 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Maryland: Bethesda
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A Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy
NCT06132893 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Maryland: Bethesda, Silver Spring
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A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures
NCT05667142 ·
Phase: Phase 3 ·
Ages: 12 Years and older ·
Sex: All (male and female)
· Maryland: Baltimore, Bethesda, Clinton
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AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy
NCT06063850 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Maryland: Baltimore, Bethesda
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An Open Label Trial to Evaluate the Efficacy and Safety of PRAX-628 in Adults With Focal Onset or Tonic-Clonic Seizures
NCT06908356 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Maryland: Bethesda
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Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics And Pharmacodynamics of SIF001 in Healthy Subjects and in Epilepsy Patients
NCT07051629 ·
Phase: Phase 1 ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Maryland: Bathesda
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Effects of Recorded Music on Clinical and EEG Seizure Activity
NCT05289934 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 4 Years to 17 Years ·
Sex: All (male and female)
· Maryland: Baltimore
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Epilepsy Learning Healthcare System (ELHS)
NCT06265103 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· Maryland: Bowie
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Evaluation and Treatment of Neurosurgical Disorders
NCT00060541 ·
Phase: Not specified ·
Ages: 4 Years to 99 Years ·
Sex: All (male and female)
· Maryland: Bethesda
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Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults
NCT05219617 ·
Phase: Phase 3 ·
Ages: 4 Years to 55 Years ·
Sex: All (male and female)
· Maryland: Baltimore, Bethesda
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Investigating Epilepsy: Screening and Evaluation
NCT03478852 ·
Phase: Not specified ·
Ages: 8 Years to 110 Years ·
Sex: All (male and female)
· Maryland: Bethesda
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Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy
NCT02531880 ·
Phase: Phase 1 ·
Ages: 18 Years to 60 Years ·
Sex: All (male and female)
· Maryland: Bethesda
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Ketogenic Diet for New-Onset Absence Epilepsy
NCT04274179 ·
Phase: Phase 3 ·
Ages: 3 Years to 12 Years ·
Sex: All (male and female)
· Maryland: Baltimore
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MEHMO Natural History and Biomarkers
NCT06019182 ·
Phase: Not specified ·
Ages: 1 Week to 100 Years ·
Sex: All (male and female)
· Maryland: Bethesda
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Medication Treatment of ADHD in Pediatric Epilepsy
NCT07594652 ·
Phase: Phase 4 ·
Ages: 6 Years to 17 Years ·
Sex: All (male and female)
· Maryland: Baltimore
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Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database
NCT02107989 ·
Phase: Not specified ·
Ages: 8 Years to 120 Years ·
Sex: All (male and female)
· Maryland: Bethesda
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Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1
NCT07563881 ·
Phase: Phase 3 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Maryland: Bethesda
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Surgery as a Treatment for Medically Intractable Epilepsy
NCT01273129 ·
Phase: Not specified ·
Ages: 8 Years to 99 Years ·
Sex: All (male and female)
· Maryland: Bethesda
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Tumor Related Epilepsy
NCT02639325 ·
Phase: Not specified ·
Ages: 8 Years to 99 Years ·
Sex: All (male and female)
· Maryland: Bethesda