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A Clinical Study to Evaluate the Safety and Efficacy of ETX101 in Infants and Children With SCN1A-Positive Dravet Syndrome
NCT05419492 ·
Phase: Phase 1, Phase 2 ·
Ages: 6 Months to 17 Years ·
Sex: All (male and female)
· Texas: Fort Worth
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A Double-blind Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen in Patients With Dravet Syndrome
NCT06872125 ·
Phase: Phase 3 ·
Ages: 2 Years to 17 Years ·
Sex: All (male and female)
· Texas: Fort Worth, Houston
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A Long-term Study of the Safety and Effectiveness of RAP-219 in Adults With Focal Onset Seizures
NCT07219407 ·
Phase: Phase 2 ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Texas: Houston
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A Phase 1/2 Study of NRTX-1001 Neuronal Cell Therapy in Drug-Resistant Bilateral Mesial Temporal Lobe Epilepsy (MTLE)
NCT06422923 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Texas: Houston
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A Phase 3, Placebo-Controlled Study to Investigate LP352 in Children and Adults With Dravet Syndrome (DS)
NCT06660394 ·
Phase: Phase 3 ·
Ages: 2 Years to 65 Years ·
Sex: All (male and female)
· Texas: Austin, Fort Worth, Houston
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A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)
NCT05716100 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Texas: Austin
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A Safety and Efficacy of Intrathecally Administered ION283 in Patients With Lafora Disease
NCT06609889 ·
Phase: Phase 1, Phase 2 ·
Ages: 10 Years to 18 Years ·
Sex: All (male and female)
· Texas: Dallas
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A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome
NCT04462770 ·
Phase: Phase 3 ·
Ages: 2 Years and older ·
Sex: All (male and female)
· Texas: Austin, Dallas
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A Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy
NCT06132893 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Texas: Cypress, Dallas, Fort Worth, Houston
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A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures
NCT05667142 ·
Phase: Phase 3 ·
Ages: 12 Years and older ·
Sex: All (male and female)
· Texas: El Paso, Houston, San Antonio
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AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy
NCT06063850 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Texas: Austin
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An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome
NCT05066217 ·
Phase: Phase 3 ·
Ages: 2 Years to 55 Years ·
Sex: All (male and female)
· Texas: Dallas, Houston
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An Examination of Whether Infrared Light Therapy Can Reduce Stress in People With Epilepsy
NCT07509177 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Texas: Houston
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An Open Label Trial to Evaluate the Efficacy and Safety of PRAX-628 in Adults With Focal Onset or Tonic-Clonic Seizures
NCT06908356 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Texas: Round Rock, Seabrook
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Brain Metabolism Observed at 3 Tesla or 7 Tesla in Health and Metabolic Disease
NCT05085704 ·
Phase: Not specified ·
Ages: 16 Years to 80 Years ·
Sex: All (male and female)
· Texas: Dallas
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Breathing Rescue for SUDEP Prevention
NCT05981755 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Texas: Houston
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Diagnosing Epilepsy To EffeCT Change
NCT07110337 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Texas: Houston
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Diffusion Tensor and Functional Connectivity Imaging in Pediatric Epilepsy: Imaging/Histology Correlation
NCT02846272 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 0 Days to 18 Years ·
Sex: All (male and female)
· Texas: Houston
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Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics And Pharmacodynamics of SIF001 in Healthy Subjects and in Epilepsy Patients
NCT07051629 ·
Phase: Phase 1 ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female)
· Texas: Cypress
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Epilepsy Learning Healthcare System (ELHS)
NCT06265103 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· Texas: Dallas
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GABA Biomarkers in Dravet Syndrome
NCT05651204 ·
Phase: Not specified ·
Ages: Up to 18 Years ·
Sex: All (male and female)
· Texas: Fort Worth
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Intracranial Investigation of Neural Circuity Underlying Human Mood
NCT05871372 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 21 Years to 70 Years ·
Sex: All (male and female)
· Texas: Houston
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Intrathecal Gene Therapy For SLC13A5 Citrate Transporter Disorder
NCT07102524 ·
Phase: Phase 1, Phase 2 ·
Ages: 2 Years to 20 Years ·
Sex: All (male and female)
· Texas: Dallas
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Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults
NCT05219617 ·
Phase: Phase 3 ·
Ages: 4 Years to 55 Years ·
Sex: All (male and female)
· Texas: Austin, Dallas
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Managing Agitated Delirium With Neuroleptics and Anti-Epileptics as a Neuroleptic Sparing Strategy
NCT05431595 ·
Phase: Phase 2, Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Texas: Houston
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Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing
NCT05418894 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 22 Years to 70 Years ·
Sex: All (male and female)
· Texas: Houston
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Mapping of Human Cognition
NCT05989893 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Texas: Houston
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Network Effects of Therapeutic Deep Brain Stimulation
NCT05600738 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Texas: Houston
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Neurobehavioral Therapy For Epilepsy And Major Depressive Disorder
NCT06695767 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female)
· Texas: Houston
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North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)
NCT01694940 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· Texas: Houston
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PRIME: PReservIng Memory in Epilepsy
NCT05608408 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female)
· Texas: Houston
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Pharmacological Modulation of Brain Oscillations in Memory Processing
NCT05594017 ·
Phase: Early Phase 1 ·
Ages: 18 Years to 55 Years ·
Sex: All (male and female)
· Texas: Dallas
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Prospective Natural History Study of POLG Disease
NCT07775872 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· Texas: Dallas, Houston
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STXBP1 and SYNGAP1 Related Disorders Natural History Study
NCT06555965 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female)
· Texas: Houston
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Stopping TSC Onset and Progression 2B: Sirolimus TSC Epilepsy Prevention Study
NCT05104983 ·
Phase: Phase 2 ·
Ages: 1 Day to 6 Months ·
Sex: All (male and female)
· Texas: Houston
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Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures
NCT07594119 ·
Phase: Phase 3 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Texas: Houston
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Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (EPIC (EPIlepsy Cell Therapy))
NCT05135091 ·
Phase: Phase 3 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female)
· Texas: Dallas, Houston
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Subcortical Arousal in Perceptual Awareness
NCT06934356 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 13 Years and older ·
Sex: All (male and female)
· Texas: Houston
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The FINTEPLA as an Anti-SUDEP Therapy in Dravet Syndrome Project
NCT07112365 ·
Phase: Phase 4 ·
Ages: 16 Years and older ·
Sex: All (male and female)
· Texas: Houston
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Understanding Prefrontal and Medial Temporal Neuronal Responses to Algorithmic Cognitive Variables in Epilepsy Patients
NCT05283811 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 10 Years to 64 Years ·
Sex: All (male and female)
· Texas: Houston
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VNS Prospective Neuromodulation of Immune and Gastrointestinal Systems
NCT03953768 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 0 Years to 60 Years ·
Sex: All (male and female)
· Texas: Houston