Clinical trials recruiting for High cholesterol
103
Recruiting trials
46
US states with sites
49
Countries
17%
Accept healthy volunteers
Phase breakdown
Drugs and treatments being studied
| Intervention | Trials |
|---|---|
| Inclisiran | 6 |
| Bempedoic acid | 3 |
| Alirocumab | 2 |
| Ezetimibe | 2 |
| MAR001 | 2 |
| SYH2053 injection | 2 |
| 2-Hydroxybenzylamine | 1 |
| AD-2284 | 1 |
| AD-228B | 1 |
| ARKOSTEROL | 1 |
| AZD4954 | 1 |
| Alirocumab 150 MG/ML [Praluent] | 1 |
Where trials are recruiting (top US states)
| State | Recruiting trials |
|---|---|
| Florida | 12 |
| North Carolina | 10 |
| Texas | 10 |
| California | 9 |
| New York | 8 |
| Alabama | 7 |
| Pennsylvania | 7 |
| Georgia | 6 |
| Maryland | 6 |
| Virginia | 6 |
| Illinois | 5 |
| Missouri | 5 |
Top cities
Boca Raton, Florida 6Jacksonville, Florida 6New York, New York 5Salt Lake City, Utah 5San Antonio, Texas 5Clearwater, Florida 4Durham, North Carolina 4Miami Lakes, Florida 4Port Orange, Florida 4Richmond, Virginia 4
Self-screener
Recruiting trials
- "Detection and Follow-up of Coronary Lesions in HeFH (DESTINY-FH Study)"
- 2-Hydroxybenzylamine (2-HOBA) to Reduce HDL Modification and Improve HDL Function in Familial Hypercholesterolemia (FH)
- A Dose-exploration Study of EDP167 in HoFH
- A Mechanistic Study of MAR001 in Adults With Elevated Triglycerides and Remnant Cholesterol
- A Phase 1b Study to Evaluate the PK of CSL300 (Clazakizumab) in Chinese Subjects With End Stage Kidney Disease (ESKD)
- A Phase III Study to Assess the Effect of FDC Laroprovstat/Rosuvastatin Compared With Laroprovstat, Rosuvastatin and Placebo on LDL-C in LLT-naïve Patients.
- A Post-Marketing Clinical Trial of Pemafibrate in Patients ｗith Hypercholesterolemia and Inadequate Response to Statins
- A Real-World Study of Long-Term Adherence and Persistence to Inclisiran, Evolocumab, and Alirocumab
- A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias
- A Study Of SHR-1918 In Participants With Hypercholesterolemia With Inadequate Lipid Control on Statins Plus PCSK9 Inhibitors
- A Study of BEBT-701 in Patients With Mild to Moderate Hypertension and Elevated Low-Density Lipoprotein Cholesterol（LDL-C）
- A Study of Bempedoic Acid in Combination With Ezetimibe and Either Rosuvastatin or Atorvastatin in Patients With Primary Hypercholesterolemia or Mixed Dyslipidemia
- A Study of Bempedoic Acid or Its Single-pill Combination Therapy With Ezetimibe in Patients With Primary Hypercholesterolaemia or Mixed Dyslipidaemia
- A Study of Enlicitide Decanoate (MK-0616, an Oral PCSK9 Inhibitor) in Children and Adolescents With Heterozygous Familial Hypercholesterolemia (MK-0616-029)
- A Study of STX-1150 in Participants With Elevated Low-Density Lipoprotein Cholesterol (LDL-C)
- A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease
- A Study on Efficacy and Safety of HST101 in Chinese Patients with Hypercholesterolemia
- A Study to Compare PK Characteristics and Safety Profiles Between AD-228B and AD-2284
- A Study to Evaluate the Effectiveness and Safety of Fixed-Dose Combination of Pitavastatin/ Ezetimibe
- A Study to Evaluate the Efficacy and Safety of Fixed-Dose Combination of Pitavastatin/Ezetimib
- A Study to Evaluate the Pharmacodynamics of a Combination of QCZ484 and Inclisiran in Participants With Hypertension and Concomitant Hypercholesterolemia
- A Study to Evaluate the SYH2053 Injection in Patients With Heterozygous Familial Hypercholesterolemia (HeFH)
- A Study to Evaluate the Safety, Efficacy of SYH2053 as Monotherapy in Chinese Participants With Non-familial Hypercholesterolemia or Mixed Hyperlipidemia
- A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4954 in Healthy Adult Participants With or Without Elevated Lipoprotein (a) (Lp[a]) Levels, and Participants With Dyslipidemia
- A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have Hypercholesterolemia
- Alirocumab in Patients on a Stable Dialysis Regimen
- An Efficacy and Safety Study of Akkermansia Muciniphila AKM Lab-01 in Hypercholesterolaemia
- Arizona CEAL: Linking Social Care With Healthcare Systems to Address SDOH
- Assessing the Effects of Corn and Avocado Oils on the Cardiometabolic Risk Factor Profile
- Assessing the Impact of Intensification of Lipid Lowering Therapy With Guidelines-based Evinacumab Administration on Coronary Plaque Volumes Measured by Coronary Computed Tomography Angiography (CCTA) in Patients With Homozygous Familial Hypercholesterolemia (HoFH)
- Assessment of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of a New Formulation of Inclisiran Containing Polysorbate 80 Compared to the Currently Marketed Formulation
- Assessment of the Prevalence of Steatotic Liver Disease Associated With Metabolic Dysfunction in Patients With Heterozygous Familial Hypercholesterolemia
- Atlantic Lipid Lowering Treatment Optimization Program
- CAPRA-EVO: a Randomized Serial PCCT Trial of Early Evolocumab After ACS
- Cardiovascular Risk in Children With Chronic Conditions Study
- Causes and Natural History of Dyslipidemias
- Child-Parent Familial Hypercholesterolemia Screening
- Clinical Decision Support for Familial Hypercholesterolemia
- Clinical Exploration Trial of YOLT-101 in the Treatment of Familial Hypercholesterolemia (FH)
- Comparing Direct vs Indirect Methods for Cascade Screening
- Complete Lifestyle Medicine Intervention Program
- Computerized Decision Support for Identification and Management of Familial Hypercholesterolemia
- Dual PCSK9 Inhibition With Inclisiran and Alirocumab in Secondary Prevention
- EAS Familial Hypercholesterolaemia Studies Collaboration
- Early Detection of Familial Hypercholesterolemia in Children
- Early Statin-Ezetimibe Combination vs. Statin Monotherapy in Stroke With Atherosclerosis
- Early Triple Lipid-Lowering Therapy With Bempedoic Acid After Acute Coronary Syndrome
- Effect of LIMICOL®-NG on Plasma LDL-cholesterol Concentration in Subjects with Moderate Hypercholesterolemia
- Effect of Two Food Supplements on Lipid Profile in Patients With Mild Hypercholesterolemia
- Effect of a Grape Seed Proanthocyanidin Extract (GSPE) on LDL Cholesterol Levels in Rotating Night Shift Workers
- Effects of Statins and Hormone Replacement Therapy in Coagulation Profile of Menopausal Women With Dyslipidemia
- Efficacy and Safety of Atorvastatin and Ezetimibe (10/10mg) Fixed Dose Combination Versus Atorvastatin (20mg) Monotherapy in Bangladeshi Population
- Efficacy and Safety of JS002 as Monotherapy in Patients With Primary Hypercholesterolaemia and Mixed Dyslipidemia
- Emergency Medicine Cardiovascular Risk Assessment for Lipid Disorders Trial
- Evaluation of Adherence, Persistence and Efficacy of Treatment With Alirocumab 300mg in Italy
- Evaluation of Adherence, Persistence and Efficacy of Treatment With PCSK9 Inhibitors in Italy
- Evaluation of the Effects of Two Dietary Supplement Formulations on the Lipid Profile in Mild Hypercholesterolemia
- FELLAShip to Better Health
- Familial Hypercholesterolemia Canada / Hypercholesterolemie Familiale Canada
- Familial Hypercholesterolemia Interpretive Comment - Nudging to Detection.
- Guideline Oriented Approach To Lipid Lowering In Asia-Pacific
- Healthy Living Anson Study
- HoFH, the International Clinical Collaborators Registry
- Identification of Asymptomatic Patients at Very High Cardiovascular Risk: Contribution of a Strategy Based on Carotid and Coronary Explorations, Compared to Simple Risk Calculation Using the European "SCORE 2" Algorithm. (IDEA-CVR)
- Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention
- Integrating Whole Genome Sequencing and Digital Twins Into the Management of Hypercholesterolemia in Emiratis
- Investigating The Potential Of A Hay-Aged Cheese To Reduce Cholesterol As Mediated By Changes In The Gut Microbiome
- LATAM LOWERS LDL-C
- Leqvio rPMS (Regulatory Post-Marketing Surveillance in Korea)
- Lipid Transport Disorder Italian Genetic Record (LIPIGEN)
- Lipoprotein Interactions and Platelet Function in Healthy Individuals and Those With Lipid Disorders
- Long-term Safety and Tolerability of Inclisiran in Participants With HeFH or HoFH Who Have Completed the Pediatric ORION-16, ORION-13, ORION-20, or ORION-19 Studies
- Low- and Moderate-intensity Statin and Clinical Outcome of Primary Prevention in Individuals Aged >70 Years: the SCOPE-70 RCT Study
- Mechanism of Ketogenic Diet-Induced Hypercholesterolemia
- Moderate-Intensity Statin Plus Ezetimibe in CKD and ASCVD
- Multicenter Study on the Evaluation of Adherence, Persistence and Efficacy of Treatment With Bempedoic Acid in Italy
- Multicenter Study on the Evaluation of Adherence, Persistence and Efficacy of Treatment With Inclisiran in Italy
- Multicomponent Intervention Study- Blood Donors With High Cholesterol
- NGGT006 Gene Therapy for Homozygous Familial Hypercholesterolemia
- National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Unified Health System Through a Multicenter Registry
- PMMHRI - Familial Hypercholesterolemia Registry
- PMMHRI-Pitavastatin Registry
- Pharmacogenomic Informed Statin Prescribing
- Pharmacy-led Transitions of Care Intervention to Improve Medication Adherence
- Phase 1a Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RN5681 in Healthy Volunteers
- Phase 1b Study of VERVE-201 in Patients With Refractory Hyperlipidemia
- Phase 3 Clinical Study Evaluating Efficacy, Safety, and Tolerability of Obicetrapib Vs Bempedoic Acid to Treat Dyslipidemia in Adults With Primary Non-familial Hypercholesterolemia or Mixed Dyslipidemia at High to Very High Cardiovascular Risk, During a Treatment Period of Approximately 84 Days
- Phase II Clinical Trial to Evaluate the Efficacy and Safety of SYH2070 Injection in Participants With Homozygous Familial Hypercholesterolemia
- Pilot Study of "Bottarga" Supplementation: A Little-known, Sustainable "Blue" Food
- Randomized Comparison of Efficacy and Safety of High-intensity Rosuvastatin/Ezetimibe Combination Versus Treat-to-target Rosuvastatin Monotherapy for Patients With Peripheral Artery or Polyvascular Disease (CARE-PVD Trial)
- Russian Familial Hypercholesterolemia Registry
- Screening for Familial Hypercholesterolemia in Children
- Study To Evaluate The Efficacy And Safety Of A Nutritional Supplement Based On Bergamot, Artichoke And Other Ingredients For Reducing Cholesterol Levels In Patients With Hypercholesterolemia (Metachol+)
- Study of MAR001 in Adults With Elevated Triglycerides and Remnant Cholesterol
- Study of the Determinants of Coronary Atherosclerosis in Familial Hypercholesterolemia (ATHERO-FH Study)
- Study to Evaluate Efficacy and Safety of Inclisiran in Children With Heterozygous Familial Hypercholesterolemia
- Study to Evaluate Safety, Tolerability and Efficacy of Inclisiran in Children With Homozygous Familial Hypercholesterolemia
- Targeting Risk Factors for Diabetes in Subjects With Normal Blood Cholesterol Using Omega-3 Fatty Acids
- Test 2 Treat: Can we Improve the Testing and Treatment of High Cholesterol in Patients Who Have Been Hospitalized for a Cardiac Event by Providing Education to Doctors and Patients?
- The Effect of Propolis Administration on Cholesterol Level in Diabetic Type 2 Patients
Related conditions
Trials recruiting for High cholesterol often also study these conditions. Each links to its own recruiting-trial list.
Hypercholesterolemia 19Familial Hypercholesterolemia 14Hypertension 1201Hypercholesterolaemia 8Obesity 1512Type 2 diabetes 891Heterozygous Familial Hypercholesterolemia (HeFH) 5Cardiovascular Diseases 164Mixed Dyslipidemia 4Hypertriglyceridemia 5
Common questions
Are these trials free to join?
Study-related care in a clinical trial is usually provided at no cost to participants, and some trials reimburse travel. Costs vary by study - the trial team will explain what is and is not covered. Confirm this directly with them.
How do I know if I am eligible for High cholesterol trials?
Each trial lists inclusion and exclusion criteria. The screener above checks stated age and sex only. The full eligibility (your medical history, current medications, test results) is assessed by the study team. Open any trial to read its criteria, then contact the site.
Is this list complete?
No. For the full list, search ClinicalTrials.gov.