Phase 3 Melanoma trials recruiting now

All Melanoma trials, every phase

Other phases for Melanoma

Phase 3 Melanoma trials

• A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma
  NCT06581406 · Phase: Phase 2, Phase 3 · Ages: No age limits stated · Sex: All (male and female) · 33 locations
• A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)
  NCT06246916 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 111 locations
• A Trial of LNS8801 With or Without Pembrolizumab in Patients With Refractory Melanoma
  NCT06624644 · Phase: Phase 2, Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 9 locations
• Adjuvant Melatonin for Uveal Melanoma
  NCT05502900 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Adjuvant Tebentafusp in High Risk Ocular Melanoma
  NCT06246149 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 15 locations
• Assessment of Short Immunotherapy After Radical Surgery of High-risk Malignant Melanoma
  NCT06488482 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 26 locations
• Camrelizumab in Combination With Apatinib and Temozolomide as First-line Treatment in Advanced Acral Melanoma
  NCT05789043 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Comparing Tunlametinib Capsules and Combination Chemotherapy in Advanced NRAS-mutant Melanoma
  NCT06008106 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Contrast-enhanced Ultrasound for Sentinel Node Detection
  NCT07310758 · Phase: Phase 2, Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• DETERMINE Trial Treatment Arm 02: Atezolizumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) Disposition
  NCT05770102 · Phase: Phase 2, Phase 3 · Ages: No age limits stated · Sex: All (male and female) · 54 locations
• DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 Gene Fusion-Positive Cancers.
  NCT05770544 · Phase: Phase 2, Phase 3 · Ages: No age limits stated · Sex: All (male and female) · 27 locations
• DETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers.
  NCT05768178 · Phase: Phase 2, Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 16 locations
• DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers.
  NCT07440290 · Phase: Phase 2, Phase 3 · Ages: 1 Year and older · Sex: All (male and female) · 27 locations
• Duration of Anti-PD-1 Therapy in Metastatic Melanoma
  NCT02821013 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 30 locations
• Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C/D Melanoma Patients
  NCT03567889 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 37 locations
• IMC-F106C Regimen Versus Nivolumab Regimens in Previously Untreated Advanced Melanoma (PRISM-MEL-301)
  NCT06112314 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 211 locations
• Immunotherapy or Targeted Therapy With or Without Stereotactic Radiosurgery for Patients With Brain Metastases From Melanoma or Non-small Cell Lung Cancer
  NCT05522660 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 15 locations
• NO Re-excision MelanomA - NORMA 2
  NCT07530887 · Phase: Phase 3 · Ages: No age limits stated · Sex: All (male and female) · 21 locations
• Neoadjuvant Darovasertib in Primary Uveal Melanoma
  NCT07015190 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 94 locations
• Nicotinamide Chemoprevention for Keratinocyte Carcinoma in Solid Organ Transplant Recipients - Pivotal Trial
  NCT05955924 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 7 locations
• OH2 Injection in Melanoma
  NCT05868707 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 30 locations
• PHP in Combination With IPI1/NIVO3 Compared to IPI3/NIVO1 Only in Patients With Uveal Melanoma Liver Metastases
  NCT06519266 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 6 locations
• Perioperative Treatment With Tranexamic Acid in Melanoma
  NCT05899465 · Phase: Phase 3 · Ages: 18 Years to 80 Years · Sex: All (male and female) · 5 locations
• Photodynamic Therapy Associated With Sonodynamic Therapy for the Treatment of Nodular Basal Cell Carcinoma
  NCT07381972 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma
  NCT06743126 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 71 locations
• SWE-NEO: Swedish NeoAdjuvant Trial Comparing Monotherapy to Combined Immunotherapy in Resectable Stage III Melanoma
  NCT06794775 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 3 locations
• Safety and Efficacy of EIK1001 in Combo With Pembro Versus Placebo and Pembro as First-Line Therapy in Patients With Advanced Melanoma.
  NCT06697301 · Phase: Phase 2, Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 107 locations
• Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma
  NCT06585410 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 52 locations
• Study to Compare Pharmacokinetics, Efficacy, Safety, and Immunogenicity of MB11 Versus EU-/US-Opdivo® in Subjects With Previously Untreated Advanced [Unresectable or Metastatic] Melanoma
  NCT07221734 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 19 locations
• Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.
  NCT05727904 · Phase: Phase 3 · Ages: 18 Years to 70 Years · Sex: All (male and female) · 81 locations
• Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)
  NCT05549297 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 82 locations
• Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain
  NCT06500455 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 270 locations
• The Cancer of the Pancreas Screening-5 CAPS5)Study
  NCT02000089 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 9 locations
• Trans-Artery/Intra-Tumor Infusion of Checkpoint Inhibitors Plus Chemodrug for Immunotherapy of Advanced Solid Tumors
  NCT03755739 · Phase: Phase 2, Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs [IGNYTE-3]
  NCT06264180 · Phase: Phase 3 · Ages: 12 Years and older · Sex: All (male and female) · 81 locations

Common questions

What does Phase 3 mean?

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Is this list complete?

No. For the full record, search ClinicalTrials.gov.