Clinical trials recruiting for Systemic Sclerosis

Phase breakdown

Drugs and treatments being studied

Where trials are recruiting (top US states)

Top cities

Self-screener

Recruiting trials

• A Phase 1 Open-label Study to Evaluate Safety in Healthy Participants and Participants With Autoimmune Diseases
  NCT07284797 · Phase: Phase 1 · Ages: 18 Years to 75 Years · Sex: All (male and female) · 1 location
• A Phase 1/2 Study of NKX019 in Subjects With Immune-Mediated Diseases (Ntrust-2)
  NCT06733935 · Phase: Phase 1, Phase 2 · Ages: 18 Years to 75 Years · Sex: All (male and female) · 18 locations
• A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease
  NCT06925542 · Phase: Phase 1 · Ages: 18 Years to 70 Years · Sex: All (male and female) · 16 locations
• A Study of AZD0120 in Autoimmune Diseases
  NCT07295847 · Phase: Phase 1 · Ages: 18 Years to 75 Years · Sex: All (male and female) · 22 locations
• A Study to Investigate the Safety and Preliminary Efficacy of ALLO-329, an Allogeneic CAR T-cell Therapy, in Adults With Autoimmune Disease
  NCT07085104 · Phase: Phase 1 · Ages: 18 Years to 74 Years · Sex: All (male and female) · 17 locations
• An Clinical Study of YTS109 Cell Injection in Subjects With Recurrent/Refractory Autoimmune Disease
  NCT06379646 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 65 Years · Sex: All (male and female) · 2 locations
• Autologous Stem Cell Transplant (ASCT) for Autoimmune Diseases
  NCT05029336 · Phase: Phase 2 · Ages: 8 Years to 25 Years · Sex: All (male and female) · 1 location
• Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis
  NCT03630211 · Phase: Phase 2 · Ages: 8 Years to 60 Years · Sex: All (male and female) · 3 locations
• CAR-T Cells in Systemic B Cell Mediated Autoimmune Disease
  NCT06347718 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• CD19-BCMA CART Cell Therapy for Refractory SLE-LN, SSc, and pSS-PAH
  NCT06947460 · Phase: Phase 1, Phase 2 · Ages: 10 Years to 65 Years · Sex: All (male and female) · 1 location
• Clinical Study on Targeted CD19 or CD19-BCMA CAR-T Therapy for Autoimmune Diseases
  NCT06548607 · Phase: Early Phase 1 · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• Deployment o the Multidisciplinary Prospective Cohort Imminent
  NCT04334031 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• EACVI Study on Multimodality Cardiovascular Imaging of Inflammatory Cardiovascular Diseases
  NCT07077304 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Exploratory Clinical Study of Anti-CD19/BCMA Universal CAR-T Cell Injection for the Treatment of Refractory Autoimmune Diseases
  NCT07558850 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• Exploratory Clinical Study on YTS109 Cell Therapy for Autoimmune Diseases
  NCT07236801 · Phase: Phase 1 · Ages: 18 Years to 65 Years · Sex: All (male and female) · 2 locations
• Exploratory Clinical Study on the Safety and Efficacy of Anti- CD19/BCMA U CAR-T Cell Injection for the Treatment of Relapsed/Refractory Autoimmune Diseases
  NCT07246096 · Phase: Early Phase 1 · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• Fourth-gen CAR T Cells Targeting BCMA/CD19 for Refractory Systemic Lupus Erythematosus (SLE)
  NCT06350110 · Phase: Phase 1, Phase 2 · Ages: 18 Years to 90 Years · Sex: All (male and female) · 1 location
• ILD-SARDs Registry and Biorepository
  NCT05007340 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Immun4Cure Cohort of Autoimmune Diseases
  NCT07515638 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• Integration of Remote Monitoring in the Management of Chronic Immunosuppressive Therapy
  NCT06544343 · Phase: Not applicable (e.g. observational or device study) · Ages: No age limits stated · Sex: All (male and female) · 3 locations
• Meir Medical Center Rheumatologic Biobank
  NCT03473912 · Phase: Not specified · Ages: 18 Years to 120 Years · Sex: All (male and female) · 1 location
• Neutrophil Extracellular Traps in Different Forms of Systemic Sclerosis
  NCT06462768 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• New Orleans Pulmonary Hypertension Biobank
  NCT03269630 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Phase I/II Study of AD-PluReceptor Plus Tafasitamab-cxix and Lymphodepleting Chemotherapy in Patients With Autoimmune Disorders
  NCT06434363 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• Rheumatology Patient Registry and Biorepository
  NCT04402086 · Phase: Not specified · Ages: 18 Years to 99 Years · Sex: All (male and female) · 2 locations
• Search for Diagnostic and Prognostic Biomarkers in Systemic Sclerosis and Inflammatory Myopathies
  NCT04917705 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Umbilical Cord Blood CD19-BCMA CART Cell Therapy for SLE-LN, SSc, andpSS PAH.
  NCT06947473 · Phase: Phase 1, Phase 2 · Ages: 6 Years to 65 Years · Sex: All (male and female) · 1 location

Related conditions

Trials recruiting for Systemic Sclerosis often also study these conditions. Each links to its own recruiting-trial list.

Common questions

Are these trials free to join?

Study-related care in a clinical trial is usually provided at no cost to participants, and some trials reimburse travel. Costs vary by study - the trial team will explain what is and is not covered. Confirm this directly with them.

How do I know if I am eligible for Systemic Sclerosis trials?

Each trial lists inclusion and exclusion criteria. The screener above checks stated age and sex only. The full eligibility (your medical history, current medications, test results) is assessed by the study team. Open any trial to read its criteria, then contact the site.

Is this list complete?

No. For the full list, search ClinicalTrials.gov.