Impact of Epileptic Discharge on the Structural Connectivity of the Developing Brain
Recruiting · NCT03268824 · Observational (researchers observe without assigning treatment) · Lead sponsor: Fondation Ophtalmologique Adolphe de Rothschild
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Focal epilepsy is associated with widespread alterations in structural brain connectivity, often present at the disease onset and related to learning disabilities. Whether ongoing seizure activity contributes to network pathology is a matter of debate. This study intends to measure the impact of seizures on structural connectivity on a local and on a global level. In children examined with intracerebral electrodes to evaluate whether a surgical cure can be proposed, we combine intracerebral stereotactic electroencephalography (EEG) recordings with diffusion weighted imaging of white matter fibers. On the local level, the study will quantify the number of deficient connections in the seizure onset zone. On a global level, the study will compare the white matter fibers of the left and right hemisphere to probe whether physiological language lateralization is preserved.
Who can take part
Inclusion criteria
- \- Drug resistant focal epilepsy
- Inclusion Criteria for control patients:
- \- without drug resistant focal epilepsy
Exclusion criteria
- Severe mental retardation (IQ \< 50)
- Lack of French-language skills
- Contraindications to MRI
- Bi-hemispherical epilepsy or affecting multiple lobes
- Exclusion Criteria for control patients:
- Severe mental retardation (IQ \< 50)
- Lack of French-language skills
- Contraindications to MRI
- Congenital pathology altering cerebral connectivity
- Parenchymal brain lesions
- Unilateral or bilateral blindness
- Unilateral or bilateral deafness
- Autistic disorders
Where it is running
1 location listed.
- Fondation Ophtalmologique A. de Rothschild - Paris, France