Biology of Juvenile Myoclonic Epilepsy
Recruiting · NCT03400371 · Observational (researchers observe without assigning treatment) · Lead sponsor: King's College London
View the official record on ClinicalTrials.gov →Interventions studied
Blood drawExisting samples
What this trial is about
The investigators are collecting genetic information through blood samples as well as clinical and EEG data from over 1000 people with Juvenile Myoclonic Epilepsy (JME) across the UK, Europe and North America. This study will draw on both existing and new samples from JME patients. These will be compared to anonymised data from samples for 2000 controls. The goal of this study is to find the genetic cause of JME. Finding the cause will help create better treatments for JME, as well as improve patient outcomes by allowing us to detect it earlier.
Who can take part
Age range
10 Years to 40 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Diagnosis of Juvenile Myoclonic Epilepsy in accordance with Consensus criteria
- Age of myoclonus onset 10-25 years
- Seizures comprising predominant or exclusive early morning myoclonus of upper extremities
- EEG interictal generalized spikes and/or polyspike and waves with normal background
- Current age 10-40 years
Exclusion criteria
- Myoclonus only associated with carbamazepine or lamotrigine therapy
- EEG showing predominant focal interictal epileptiform discharges or abnormal background
- Any evidence of progressive or symptomatic myoclonus epilepsy or focal seizures
- Global learning disability
- Dysmorphic syndrome
- Unable to provide informed consent
- Regrettably, we are currently unable to accept self-referrals to the BIOJUME study.
Where it is running
15 locations listed across 2 US states.
- Mount Sinai-Beth Israel Medical Center - New York, New York, United States
- St Luke's Roosevelt Hospital - New York, New York, United States
- Nationwide Children's Hospital - Columbus, Ohio, United States
- Danish National Epilepsy Centre - Dianalund, Denmark
- Vestre Viken Health Trust, Oslo - Drammen, Norway
- Walton Centre for Neurology and Neurosurgery - Liverpool, United Kingdom
- Royal London Hospital - London, United Kingdom
- St Thomas' Hospital - London, United Kingdom
- King's College Hospital NHS Trust - London, United Kingdom
- University Robert Debré - Paris, France
- Charles University - Prague, Czechia
- Commissione Genetica Lega Italiana contro l'Epilepssia - Roma, Italy
- Swansea University - Swansea, United Kingdom
- Tallinn Children's Hospital - Tallinn, Estonia
- Hospital for Sick Kids - Toronto, Ontario, Canada