Etiology and Treatment of Neonatal Seizure
Recruiting · NCT03822741 · Observational (researchers observe without assigning treatment) · Lead sponsor: Children's Hospital of Fudan University
View the official record on ClinicalTrials.gov →What this trial is about
Genetic diagnosis for neonates suffering from epilepsy has important implications for treatment, prognosis, and development of precision medicine strategies. Investigator performed exome sequencing (ES) or targeted sequencing on neonates with seizure onset within the first month of life. Investigator subgrouped our patients based on the onset age of seizure into neonatal and before 1 year (1-12 months), to compare the clinical and genetic features and treatment strategies.
Who can take part
Age range
Up to 12 Months
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- severe seizures in neonates or generalized epilepsy or intractable epilepsy in infancy with generalized tonic-clonic seizures,
- seizures onset before 1 year of age,
- epileptic syndromes/epileptic-encephalopathies with unknown etiology.
Exclusion criteria
- Patients were excluded if they had traumas, central nervous system infections, hypoxic-ischemic encephalopathy, vascular events, systemic infections, and diagnosed metabolic disorders, and pathogenic copy-number variants were identified using array-based comparative genomic hybridization (CGH).
Where it is running
1 location listed.
- Children Hospital of Fudan University - Shanghai, Shanghai Municipality, China