Evaluation of Deep Brain Stimulation (DBS) of the Right Operculum 3 (OP3) in Permanent Non-pulsatile Disabling Tinnitus (TINNOP3-DBS)

Inclusion criteria

• Between 18 and 75 years old,
• Uni or bilateral permanent non-pulsatile tinnitus, without associated vestibular pathology, with or without hearing loss,
• Severe tinnitus resistant to treatment failure,
• Tinnitus intensity on the Visual Analog Scale (VAS) ≥ 7,
• Presenting a quality of life score on the Tinnitus Handicap Inventory (THI) questionnaire\> 76 (= grade 5),
• Social security affiliates or beneficiaries of such a scheme
• Informed and written consent signed by the patient.

Exclusion criteria

• Vestibular dysfunction (balance disorder),
• Epilepsy,
• Intercurrent serious pathology,
• Brain tumor,
• Contraindication to surgery or anesthesia,
• History of cerebral infection with herpesvirus,
• With a contraindication to the practice of MRI, MEG, Computerized Tomography (CT) scan,
• Under anticoagulants and antiaggregants (Anti vitamin K, low molecular weight heparin, aspirin and derivatives, clopidogrel antiplatelet agents and assimilated, new oral anticoagulants (NACO)) for which a therapeutic window can not be opened within 3 months before and after the surgery,
• Included in another therapeutic protocol,
• Progressive dementia or psychiatric illness,
• Presenting a suicidal risk deemed important for less than 3 months (Montgomery and Asberg depression scale (MADRS): suicidality item (item 10) score\> 2),
• Enforced hospitalisation,
• Pregnant, parturient or breastfeeding, lack of contraception in patients with the capacity to procreate,
• Subject to a legal protection measure,
• Deprived of liberty by judicial or administrative decision,
• Isolated patient without any contact in case of emergency.