Pathogenesis of Pediatric Nonalcoholic Fatty Liver Disease (NAFLD)
Recruiting · NCT04634643 · Observational (researchers observe without assigning treatment) · Lead sponsor: Yale University
View the official record on ClinicalTrials.gov →Interventions studied
Usual diet and physical activity
What this trial is about
The main aim of the study is to discover the mechanisms underlying the pathophysiology of NAFLD in obese youth.
Who can take part
Age range
12 Years to 18 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Good general health, taking no medication on a chronic basis;
- age 12 to 18 years, in puberty (girls and boys: Tanner stage II-V);
- BMI \>85th for obese cohort;
Exclusion criteria
- Baseline creatinine \>1.0 mg; pregnancy;
- the presence of endocrinopathies (e.g. Cushing syndrome);
- cardiac or pulmonary or other significant chronic illness;
- adolescents with a psychiatric disorder or with substance abuse;
- monogenic obesity syndromes;
- use of drugs affecting intrahepatic fat content (e.g.; liraglutide, fish oil, etc.).
Where it is running
1 location listed across 1 US state.
- Yale New Haven Hospital - New Haven, Connecticut, United States