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A Feasibility Study of Mass-Based Response Drug Screening to Guide Personalized Hyperthermic Intraperitoneal Chemotherapy for High-Grade Appendiceal and Colorectal Adenocarcinoma With Peritoneal Metastasis
NCT07291180 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 81 Years ·
Sex: All (male and female) · 1 location
-
A Trial Comparing High-Flow Nasal Cannula Versus Noninvasive Ventilation on Reintubation and Post-Extubation Respiratory Failure in High-Risk Patients With Systolic Heart Failure
NCT06671015 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
AB821 in Adult Participants With Locally Advanced or Metastatic Solid Tumors
NCT07027488 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Aerobic Exercise and Obsessive-Compulsive Disorder Symptoms
NCT07103902 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 64 Years ·
Sex: All (male and female) · 1 location
-
Anticoagulation in ICH Survivors for Stroke Prevention and Recovery
NCT03907046 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 187 locations
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Assessing the Effectiveness of Digital Wellness Modules on Perceived Quality of Life
NCT05810259 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female) · 1 location
-
Baduanjin With Resistance Training Program
NCT06853132 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 45 Years and older ·
Sex: All (male and female) · 1 location
-
Brain Network Changes Accompanying and Predicting Responses to Pharmacotherapy in OCD
NCT04131829 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female) · 1 location
-
Cardiovascular Disease Risk in Women With Endometriosis
NCT03746535 ·
Phase: Early Phase 1 ·
Ages: 18 Years to 45 Years ·
Sex: Female · 1 location
-
Circulating Tumor DNA
NCT06923527 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 7 locations
-
Continuous Glucose Monitors (CGMs) for All: Studying the Impact of Expanding CGM Access
NCT06658067 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Craving Network Neurofeedback
NCT06426693 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 60 Years ·
Sex: All (male and female) · 1 location
-
Digoxin In NASH (CODIN)
NCT06588699 ·
Phase: Phase 2 ·
Ages: 18 Years to 75 Years ·
Sex: All (male and female) · 2 locations
-
Dose-Deescalated 3-Fraction Stereotactic Body Radiotherapy For Centrally Located Lung Cancer
NCT04210492 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 6 locations
-
Effect of the Thrive AI Health App on Lifestyle Behaviors and Quality of Life
NCT07376655 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 40 Years and older ·
Sex: All (male and female) · 1 location
-
Efficacy of Valbenazine for the Treatment of Trichotillomania in Adults
NCT05207085 ·
Phase: Phase 2 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female) · 1 location
-
Ertugliflozin in Chronic Heart Failure
NCT04438213 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 2 locations
-
Evaluating the Efficacy of a Mobile Application in Postoperative Rehabilitation
NCT06407427 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Evaluation of a Mobile App Program for Coping With Cancer
NCT06923501 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Evaluation of the Clinical and Psychological Impact of Vitamin D Replacement in Adolescent Females at Risk for Polycystic Ovarian Syndrome (PCOS)
NCT04355572 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 13 Years to 21 Years ·
Sex: Female · 1 location
-
Expanding Medication-Assisted Therapies in Central Asia
NCT05579470 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female) · 4 locations
-
Exploring Water-free Sodium Storage
NCT06872645 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Exploring the Utility of [18F]3F4AP for Demyelination Imaging
NCT06999434 ·
Phase: Phase 1 ·
Ages: 18 Years to 90 Years ·
Sex: All (male and female) · 1 location
-
FCHV-HTN Implementation Trial in Nepal
NCT06081010 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 30 Years and older ·
Sex: All (male and female) · 1 location
-
Genetic Basis of the Risk and Consequences of Cannabis Exposure in Humans
NCT06058702 ·
Phase: Phase 1 ·
Ages: 21 Years to 60 Years ·
Sex: All (male and female) · 1 location
-
HIV and Alcohol Research Center Focused on Polypharmacy (HARP) Pilot 2 (2nd HARP Pilot Intervention)
NCT06513819 ·
Phase: Phase 1 ·
Ages: 50 Years and older ·
Sex: All (male and female) · 1 location
-
Iadademstat + SBRT With Atezo in ES-SCLC
NCT07113691 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Identifying and Characterizing Preclinical MS
NCT05787795 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning
NCT01730781 ·
Phase: Not specified ·
Ages: 18 Years to 55 Years ·
Sex: Male · 1 location
-
Imaging Depression in Parkinson's Disease
NCT06402955 ·
Phase: Phase 2 ·
Ages: 40 Years to 80 Years ·
Sex: All (male and female) · 1 location
-
Integrated e-Health (Electronic Health) for HIV and Substance Use Disorders in Justice Involved Women
NCT05547048 ·
Phase: Phase 4 ·
Ages: 18 Years and older ·
Sex: Female · 2 locations
-
Integrating PrEP Decision Making Into Counseling in Sexual and Reproductive Health Clinics
NCT06684613 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: Female · 1 location
-
Intestinal Immunity in Neurologic Disease
NCT06329453 ·
Phase: Not specified ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female) · 1 location
-
Lifestyle, Exercise, And Nutrition (LEAN) Trial on Pathologic Complete Response in TNBC
NCT07066189 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: Female · 1 location
-
Mechanisms of Diuretic Resistance in Heart Failure, Aim 1
NCT05323487 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Mechanisms of Diuretic Resistance in Heart Failure, Aim 2
NCT05753059 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Mechanisms of Diuretic Resistance in Heart Failure, Aim 3
NCT06209359 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Mechanistic Studies of Psilocybin in Headache Disorders
NCT06464367 ·
Phase: Early Phase 1 ·
Ages: 21 Years to 70 Years ·
Sex: All (male and female) · 1 location
-
Music for Pain and Dementia
NCT07602283 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 50 Years to 80 Years ·
Sex: All (male and female) · 2 locations
-
OPTImizing Malaria And HIV Treatment in a Shifting Landscape in Africa
NCT06967519 ·
Phase: Phase 4 ·
Ages: 5 Years to 17 Years ·
Sex: All (male and female) · 2 locations
-
Obesity Complicating Type 1 Diabetes: GLP-1 Analogue Anti-obesity Treatment
NCT06411210 ·
Phase: Phase 2 ·
Ages: 18 Years to 30 Years ·
Sex: All (male and female) · 1 location
-
Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 3 Semaglutide
NCT07040592 ·
Phase: Phase 2 ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female) · 1 location
-
Open-Label Psilocybin Study in Transdiagnostic Population
NCT06442423 ·
Phase: Phase 1 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 2 locations
-
PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence Study
NCT06713616 ·
Phase: Phase 3 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 8 locations
-
PRIDE III Prison Interventions and HIV Prevention Collaboration
NCT06962033 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female) · 5 locations
-
Parent-Based Treatment for Adolescent Anxiety
NCT07219992 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 14 Years to 17 Years ·
Sex: All (male and female) · 1 location
-
Pathogenesis of Pediatric Nonalcoholic Fatty Liver Disease (NAFLD)
NCT04634643 ·
Phase: Not specified ·
Ages: 12 Years to 18 Years ·
Sex: All (male and female) · 1 location
-
Peer-led Implementation of TB-HIV Education and Adherence Counseling in Uganda
NCT05917210 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Peru Decentralized HIV Care
NCT05910268 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female) · 2 locations
-
Promoting Palliative Care for People With Heart Failure
NCT06933875 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female) · 2 locations
-
Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain
NCT07639060 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Real-Time Monitoring of Heart Failure Across the Yale New Haven Health System
NCT04237701 ·
Phase: Not specified ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Reducing Stigma in People Who Inject Drugs (PWID) With HIV Using a Rapid Start Antiretroviral Therapy Intervention (ART)
NCT06541028 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female) · 3 locations
-
Reversal of Lipid-Induced Insulin Resistance
NCT02193295 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 90 Years ·
Sex: All (male and female) · 2 locations
-
Reversibility of Brain Glucose Transport in Type 2 Diabetes Mellitus (T2DM)
NCT05776563 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 60 Years ·
Sex: All (male and female) · 1 location
-
Rheumatology Patient Registry and Biorepository
NCT04402086 ·
Phase: Not specified ·
Ages: 18 Years to 99 Years ·
Sex: All (male and female) · 2 locations
-
SV2 PET Imaging With [11C]APP311
NCT03995121 ·
Phase: Not specified ·
Ages: 18 Years to 85 Years ·
Sex: All (male and female) · 1 location
-
SV2A & TSPO PET Imaging Measures to Reveal Mechanisms of HIV Neuropathogenesis During Antiretroviral Therapy
NCT05586581 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years to 80 Years ·
Sex: All (male and female) · 1 location
-
Saci Nivo Rela for TNBC
NCT06963905 ·
Phase: Phase 1, Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Shared Decision Making to Treat Or Prevent (STOP) HIV in Criminal Legal Involved Populations (R33)
NCT07223398 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: All (male and female) · 4 locations
-
Sipuleucel-T Combined With Bipolar Androgen Therapy in Men With mCRPC
NCT06100705 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
-
Sodium-Glucose Cotransporter-2 Inhibitor for Patients With Acute Cardiorenal Syndrome
NCT07273838 ·
Phase: Phase 2 ·
Ages: 18 Years to 85 Years ·
Sex: All (male and female) · 2 locations
-
Stress and Pain in People Living With HIV
NCT06784908 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 68 Years ·
Sex: All (male and female) · 1 location
-
Subcortical Arousal in Perceptual Awareness
NCT06934356 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 13 Years and older ·
Sex: All (male and female) · 8 locations
-
The Efficacy of Psilocybin Therapy for Depression in Parkinson's Disease
NCT07610369 ·
Phase: Phase 2 ·
Ages: 40 Years to 80 Years ·
Sex: All (male and female) · 1 location
-
The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects
NCT05786066 ·
Phase: Phase 2 ·
Ages: 21 Years to 65 Years ·
Sex: All (male and female) · 1 location
-
The OBSERVE Protocol
NCT06725277 ·
Phase: Not specified ·
Ages: No age limits stated ·
Sex: All (male and female) · 8 locations
-
The SUGAR Study; SBRT and Relugolix) for Prostate Cancer
NCT06111781 ·
Phase: Phase 2 ·
Ages: 18 Years and older ·
Sex: Male · 4 locations
-
Toward a Computationally-Informed, Personalized Treatment for Hallucinations
NCT04366518 ·
Phase: Early Phase 1 ·
Ages: 18 Years to 65 Years ·
Sex: All (male and female) · 1 location
-
Transcranial Direct Current Stimulation and Extinction in Obsessive Compulsive Disorder
NCT06834217 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 70 Years ·
Sex: All (male and female) · 1 location
-
Transcranial Magnetic Stimulation (TMS) to Treat Depression in Autism Spectrum Disorder
NCT06142955 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years to 40 Years ·
Sex: All (male and female) · 1 location
-
Trauma-informed Approach to Timely Detection and Management of Early Postpartum Hypertension
NCT05884190 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 18 Years and older ·
Sex: Female · 3 locations
-
Ultrasound Effects on Glycemic Control in T2DM
NCT05354947 ·
Phase: Not applicable (e.g. observational or device study) ·
Ages: 21 Years to 75 Years ·
Sex: All (male and female) · 1 location
-
Unmitigated Aldosterone Signaling During Standard Clinical MRA Dosing
NCT07281014 ·
Phase: Phase 4 ·
Ages: 18 Years and older ·
Sex: All (male and female) · 1 location
Yale University is the lead sponsor of 74 recruiting
trials.