Localizing Epileptic Networks Using MRI and iEEG
Recruiting · NCT04649008 · Interventional (participants receive a specific treatment) · Lead sponsor: University of Pennsylvania
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Upon successful completion of this study, the investigators expect the study's contribution to be the development of noninvasive imaging biomarkers to predict IEEG functional dynamics and epilepsy surgical outcomes. Findings from the present study may inform current and new therapies to map and alter seizure spread, and pave the way for less invasive, better- targeted, patient-specific interventions with improved surgical outcomes. This research is relevant to public health because over 20 million people worldwide suffer from focal drug-resistant epilepsy and are potential candidates for cure with epilepsy surgical interventions.
Who can take part
Inclusion criteria
- Patients with medication-refractory epilepsy
- Planned intracranial EEG (IEEG) placement
- Hypothesized to have temporal lobe epilepsy
Exclusion criteria
- Contraindication to 3T MRI (e.g. metal implants or claustrophobia), clinical features that typically preclude the use of IEEG (e.g. pregnancy), prior intracranial surgery or device, and IEEG findings that are non-diagnostic (e.g. seizure onset zone(s) not identified)
Where it is running
1 location listed across 1 US state.
- University of Pennsylvania - Philadelphia, Pennsylvania, United States