Rollover Study for Patients With Sickle Cell Disease Who Have Completed a Prior Novartis-Sponsored Crizanlizumab Study
Recruiting · NCT04657822 · Interventional (participants receive a specific treatment) · Lead sponsor: Novartis Pharmaceuticals
View the official record on ClinicalTrials.gov →Interventions studied
Crizanlizumab
What this trial is about
This is a multi-center multi-national rollover study to allow continued access to crizanlizumab for patients with sickle cell disease (SCD) who are on crizanlizumab treatment in a Novartis-sponsored study (parent study) and are benefiting from the treatment as judged by the investigator.
Who can take part
Age range
6 Months to 100 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 4
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Written informed consent/assent, according to local guidelines, signed by the adult patients. In the population under 18 years, it will be signed by the patient and/or by the parents or legal guardian prior to enrolling in the rollover study and receiving study medication
- SCD patient currently enrolled in a Novartis-sponsored study receiving crizanlizumab and has fulfilled all the requirements in the parent study. Patient is currently benefiting from the treatment with crizanlizumab as determined by the investigator and has completed the treatment schedule as planned in the parent study
- Patient has demonstrated compliance to the planned visit schedule in the parent study, and in the opinion of the investigator has shown willingness and ability to comply with future visit schedules
Exclusion criteria
- Patient had permanently discontinued from crizanlizumab study treatment in the parent study before the parent study completion
- Ongoing/unresolved treatment-related Grade 3 or higher AEs, and/or any ongoing AE requiring dose interruption. Patients meeting all other eligibility criteria may be enrolled once toxicities have resolved unless those toxicities were grade 4
- Concurrent participation in any other investigational clinical trial other than the parent study or plan to participate in any other investigational clinical trial
- Pregnant or nursing women
- Women of childbearing potential who are unwilling to be on highly effective contraceptives during dosing and until 15 weeks after stopping treatment with crizanlizumab
- SCD patients who do not meet parent study protocol criteria to continue with crizanlizumab
Where it is running
31 locations listed across 6 US states.
- University Of Alabama - Birmingham, Alabama, United States
- Childrens National Hospital - Washington D.C., District of Columbia, United States
- Augusta University Georgia - Augusta, Georgia, United States
- East Carolina University - Greenville, North Carolina, United States
- East Carolina University - Greenville, North Carolina, United States
- Childrens Hospital of Philadelphia - Philadelphia, Pennsylvania, United States
- Cook Childrens Medical Center - Fort Worth, Texas, United States
- Novartis Investigative Site - Barcelona, Spain
- Novartis Investigative Site - Beirut, Lebanon
- Novartis Investigative Site - Brussels, Belgium
- Novartis Investigative Site - Créteil, France
- Novartis Investigative Site - Heidelberg, Germany
- Novartis Investigative Site - Khoudh, Oman
- Novartis Investigative Site - Laken, Belgium
- Novartis Investigative Site - Liège, Belgium
- Novartis Investigative Site - Madrid, Spain
- Novartis Investigative Site - Montería, Colombia
- Novartis Investigative Site - Paris, France
- Novartis Investigative Site - Paris, France
- Novartis Investigative Site - Tripoli, Lebanon
- Novartis Investigative Site - Hatay, Antakya, Turkey (Türkiye)
- Novartis Investigative Site - Barranquilla, Atlántico, Colombia
- Novartis Investigative Site - Valledupar, Cesar Department, Colombia
- Novartis Investigative Site - Salvador, Estado de Bahia, Brazil
- Novartis Investigative Site - Padova, PD, Italy
- Novartis Investigative Site - Adana, Saricam, Turkey (Türkiye)
- Novartis Investigative Site - Ribeirão Preto, São Paulo, Brazil
- Novartis Investigative Site - São Paulo, São Paulo, Brazil
- Novartis Investigative Site - Orbassano, TO, Italy
- Novartis Investigative Site - Cali, Valle del Cauca Department, Colombia
- Novartis Investigative Site - Adana, Yuregir, Turkey (Türkiye)