Clinical trials recruiting for Sickle cell disease
172
Recruiting trials
39
US states with sites
42
Countries
16%
Accept healthy volunteers
Phase breakdown
Drugs and treatments being studied
| Intervention | Trials |
|---|---|
| Alemtuzumab | 7 |
| Hydroxyurea | 6 |
| Sirolimus | 6 |
| Total Body Irradiation | 6 |
| Fludarabine | 5 |
| Cyclophosphamide | 3 |
| Etavopivat | 3 |
| Mycophenolate Mofetil | 3 |
| Thiotepa | 3 |
| Abatacept | 2 |
| Busulfan | 2 |
| Crizanlizumab | 2 |
Where trials are recruiting (top US states)
| State | Recruiting trials |
|---|---|
| Georgia | 25 |
| Ohio | 24 |
| Tennessee | 23 |
| Pennsylvania | 22 |
| California | 21 |
| Maryland | 21 |
| New York | 21 |
| Illinois | 20 |
| North Carolina | 20 |
| Alabama | 18 |
| Texas | 15 |
| Missouri | 14 |
Top cities
Atlanta, Georgia 21Chicago, Illinois 19Memphis, Tennessee 19Birmingham, Alabama 16Bethesda, Maryland 15Philadelphia, Pennsylvania 15New York, New York 13St Louis, Missouri 13Washington D.C., District of Columbia 13Boston, Massachusetts 12
Self-screener
Recruiting trials
- 131I-apamistamab-based Conditioning for Hematopoietic Stem Cell Transplant (HSCT) in Advanced Sickle Cell Disease (SCD)
- A Long-term Follow-up Study in Patients Who Received BEAM-101
- A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)
- A Phase 2 Open-label Study to Evaluate the Activity of Etavopivat on Transcranial Doppler Velocities in Pediatric Patients With Sickle Cell Disease Who Are at Increased Risk for Primary Stroke
- A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD
- A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease
- A Pilot Study on Neuroimaging in SCD: Part of The Boston Consortium to Cure Sickle Cell Disease
- A Real-World Registry of Chronic Wounds and Ulcers
- A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia
- A Smart Phone Application to Improve Adoption of the 2024 Kidney Disease Improving Global Outcomes (KDIGO) Chronic Kidney Disease (CKD) Guidelines
- A Socio-ecological Approach for Improving Self-management in Adolescents With SCD
- A Study of Immune Suppression Treatment for People With Sickle Cell Disease or β-Thalassemia Who Are Going to Receive an Allogeneic Hematopoietic Cell Transplantation (HCT)
- A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell Disease
- A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
- A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease
- A Study to Evaluate the Pharmacokinetics and Safety of Etavopivat in Pediatric Patients With Sickle Cell Disease
- A Study to Investigate the Effect of Mitapivat on Transfusion Burden in Subjects With Sickle Cell Disease (SCD)
- A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)
- A Trial to Assess Haploidentical T-depleted Stem Cell Transplantation in Patients With SCD
- ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders
- ATHNdataset Registry
- Acceptance and Commitment Therapy for Adolescents and Young Adults With Sickle Cell Disease
- Achieving Understanding of the Natural History of Sickle Cell Trait (AUNT)
- Adapting the FACETS Program to Sickle Cell Disease
- Advancing Feasibility and Acceptability of Digital Cognitive Rehabilitation in Sickle Cell Disease
- Alendronate for Osteonecrosis in Adults With Sickle Cell Disease
- Allo HSCT for High Risk Hemoglobinopathies
- AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletion
- Arginine Therapy for the Treatment of Pain in Children With Sickle Cell Disease
- Assessing Molecular Mechanisms and Effects of Music Therapy in Youth With Sickle Cell Disease Using Single-cell RNA-sequencing
- Autologous Testicular Tissue Transplantation
- Blood Sampling for Research Related to Sickle Cell Disease
- Bone Loss, Physical Function and Frailty in Older Women With Sickle Cell Trait Sickle Cell Trait
- CS-206 in Patients With Sickle Cell Disease
- Cannabidiol in Sickle Cell Disease
- Cannabinoids for the Reduction of Inflammation and Sickle Cell Related Pain
- Cerebral Oxygen Metabolism in Children
- Cerebrovascular Reactivity Measurements With High-Density Diffuse Optical Tomography
- Clinical and Biomarker Effects of Depot Medroxyprogesterone Acetate in Females With Sickle Cell Disease
- Cognitive Remediation Intervention to Prepare for Transition of Care
- Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants
- Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Transplantation to Disease Modifying Therapy in Pediatric Patients With Sickle Cell Disease
- Cooperative Assessment of Late Effects for SCD Curative Therapies
- Cutaneous Hydration Assessment in SCD
- Data Collection Study of Patients With Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT With RIC
- Delivering Patient-Facing Evidence-Based Guidelines Through mHealth to Adults With Sickle Cell Disease
- Determination of Red Cell Survival in Sickle Cell Disease and Other Hemoglobinopathies Using Biotin Labeling
- Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders
- Dietary Intake and Dietary Behaviors in Adults With Sickle Cell Disease
- Domestication and Implementation of the PEN-Plus Clinical Model in the Zambian Health System
- Early Life Exposures Among Children With Sickle Cell Disease
- Early Screening and Treatment of Heart Complication in Sickle Cell Disease
- Effect of EMDR for Reduction of Pain Interference in Children With Sickle Cell Disease
- Effect of MitoQ on Platelet Function and Reactive Oxygen Species Generation in Patients With Sickle Cell Anemia
- Effect of Virtual Reality Technology for Pain Management of Vaso-Occlusive Crisis in Patients With Sickle Cell Disease
- Effectiveness of Nontraditional Hydroxyurea Algorithms: Novel and Clinical Evaluations (ENHANCE)
- Efficacy Safety Study of Gene Therapy for Sickle Cell DiseaseSCD Using Autologous CD34+ Cells Transduced ex Vivo, Carrying a Corrected Globin Gene and a Silencing RNA.
- Efficacy and Safety of SIL-8301 for Control of Hemolysis in a Uniform Sickle Cell Disease Endotype
- Efficacy and Safety of Tocilizumab for Acute Chest Syndrome Treatment in Patients With Sickle Cell Disease
- Efficacy of Liberal Versus Restricted IV Fluid Approach in the Management of Sickle Cell Vaso-Occlusive Crisis
- Empowering Adolescents and Young Adults With Sickle Cell Disease as Partners in Treatment Decision Making (EMPOWER-AYA)
- Escalating Doses of VAS-101 in Subjects With Stable Sickle Cell Disease
- European Rare Blood Disorders Platform (ENROL)
- Evaluation of Efficacy and Safety of a Single Dose of CTX001 in Participants With Transfusion-Dependent β-Thalassemia and Severe Sickle Cell Disease
- Evaluation of an Information Management and Communication System for Population-wide Point-of-Care Infant Sickle Cell Disease Screening
- Exercise in Child Health
- Exploratory Study on Global Reflexology in Sickle Cell Disease
- FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare Diseases
- Feasibility and Efficacy of Attentional-Control Training in Sickle Cell Disease
- Fetal Cell Receptors Repertoire
- Functional Ovarian Reserve in Sickle Cell Disease
- Gene Correction in Autologous CD34+ Hematopoietic Stem Cells (HbS to HbA) to Treat Severe Sickle Cell Disease
- Gene Editing For Sickle Cell Disease
- Gene Therapy Communication: Use of a Needs Assessment to Drive Decision-AIDS for Gene Therapy for Rare Diseases (GENETX)
- Genotype -Phenotype Correlation of PKLR Variants With Pyruvate Kinase, 2,3-Diphosphglycerate and Adenosine Triphosphate Activities in Red Blood Cells of People With Sickle Cell Disease
- HPC Offered for PRESERVE Expansion
- Haploidentical Donor Hematopoietic Cell Transplant for Sickle Cell Disease
- Haploidentical Transplantation With Pre-Transplant Immunosuppressive Therapy for Patients With Sickle Cell Disease
- Hematopoietic Stem Cell BCL11A Enhancer Gene Editing for Severe β-Hemoglobinopathies
- Hemoglobin Disorders in Egypt: Sickle Cell Disease Ain Shams University Institutional Registry
- High-flow Oxygen for Vaso-occlusive Pain Crisis
- Hydroxyurea Exposure Limiting Pregnancy and Follow-Up Lactation
- Impact of Regional Anesthesia on Inflammatory Mechanisms During Vaso-occlusive Crisis in Sickle Cell Patients
- Integrative Diagnosis for SCD and Other RADs
- Integrative Medicine in Pain Management in Sickle Cell Disease, 2.0
- Integrative Training Program for Pediatric Sickle Cell Pain
- Intravenous L-Citrulline for Vaso-occlusive Pain Episode in Sickle Cell Disease
- Investigation Into the Use of BAH243 Lentiviral Vector for Gene Therapy in Treating Sickle Cell Disease
- Investigation of the Genetics of Hematologic Diseases
- Let's Get REAL: Family Health Communication Tool in Pediatric Stem Cell Transplant and Cellular Therapy
- Lidocaine for Opioid Sparing in Vaso-occlusive Crisis of Sickle Cell Disease
- Long-term Endurance Training in Sickle Cell Disease Patients: Impact on Clinical Profile, Physical Fitness, and Quality of Life.
- Lung Ultrasound in Pediatric Acute Chest Syndrome
- MULTIsite Feasibility of MUSIc Therapy to Address Quality Of Life in Sickle Cell Disease
- Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease
- Mindfulness-Based Intervention for Pain and Sleep in Adolescents and Young Adults With Sickle Cell Disease
- Minimizing Toxicity in HLA-identical Sibling Donor Transplantation for Children With Sickle Cell Disease
- Molecular and Cellular Basis of Severe Forms of Dengue in Sickle Cell Patients
- Morphine Clearance and Glomerular Filtration in Sickle Cell Patients in Crisis in Intensive Care
- Multi Disciplinary Sickle Cell Disease Obstetrics Care Program in Ghana
Related conditions
Trials recruiting for Sickle cell disease often also study these conditions. Each links to its own recruiting-trial list.
Sickle Cell Anemia 10Thalassemia 8Sickle Cell Disease (SCD) 7Beta-Thalassemia 5Vaso-Occlusive Pain Episode in Sickle Cell Disease 4Sickle Cell Trait 4Hemoglobinopathies 4Acute Chest Syndrome 4Vaso-occlusive Crisis 3Vaso-Occlusive Crises 3
Common questions
Are these trials free to join?
Study-related care in a clinical trial is usually provided at no cost to participants, and some trials reimburse travel. Costs vary by study - the trial team will explain what is and is not covered. Confirm this directly with them.
How do I know if I am eligible for Sickle cell disease trials?
Each trial lists inclusion and exclusion criteria. The screener above checks stated age and sex only. The full eligibility (your medical history, current medications, test results) is assessed by the study team. Open any trial to read its criteria, then contact the site.
Is this list complete?
No. For the full list, search ClinicalTrials.gov.