ERP to Improve Functioning in Veterans With OCD
Recruiting · NCT05240924 · Interventional (participants receive a specific treatment) · Lead sponsor: VA Office of Research and Development
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Obsessive compulsive disorder (OCD) is a debilitating psychiatric illness impacting work, social, and family functioning. Exposure and Response Prevention (ERP) is the sole evidence-based psychotherapy for OCD; however, no randomized controlled trials (RCTs) have examined the effectiveness of ERP among Veterans or individuals with both OCD and posttraumatic stress disorder (PTSD). This 4-year Hybrid Type I trial will compare outcomes of ERP to those of a control condition among Veterans with OCD. Primary and secondary aims will examine whether Veterans' functioning, quality of life, and OCD symptoms differ between the ERP and control in the full sample of Veterans with OCD, and in the half of the sample with both OCD and PTSD. The tertiary aim is to conduct a mixed-methods formative evaluation of the implementation potential of ERP in VA mental health settings.
Who can take part
Inclusion criteria
- Veterans having a primary diagnosis of Obsessive Compulsive Disorder (OCD)(50% of sample) and comorbid OCD and Post-traumatic stress disorder (PTSD) (50% of sample) who are receiving care from the Michael E. DeBakey VA Medical Center (MEDVAMC) in Houston, TX; the Ralph H. Johnson VA Medical Center in Charleston, SC; the VISN 20 Clinical Resource Hub which provides telehealth services to Washington, Oregon, and Alaska: the VISN 2 Clinical Resource Hub which provides telehealth services to New Jersey, New York, and northern Pennsylvania, and the VISN 6 Clinical Resource Hub which provides telehealth services to North Carolina and Virginia.
- Willingness to participate in Exposure and Response Prevention(ERP)
Exclusion criteria
- Significant cognitive impairment or conditions that threaten safety (current psychosis, mania, imminent suicidality including plan or intent, and treatment-interfering moderate to severe substance use).
- Potential participants taking psychotropic medications must be on a stable dose of these medications for at least 6 weeks prior to study enrollment.
Where it is running
19 locations listed across 8 US states.
- East Orange Campus of the VA New Jersey Health Care System, East Orange, NJ - East Orange, New Jersey, United States
- VA Western New York Healthcare System, Buffalo, NY - Buffalo, New York, United States
- VA NY Harbor Healthcare System, New York, NY - New York, New York, United States
- Northport VA Medical Center, Northport, NY - Northport, New York, United States
- James J. Peters VA Medical Center, Bronx, NY - The Bronx, New York, United States
- Asheville VA Medical Center, Asheville, NC - Asheville, North Carolina, United States
- Durham VA Medical Center, Durham, NC - Durham, North Carolina, United States
- Fayetteville VA Medical Center, Fayetteville, NC - Fayetteville, North Carolina, United States
- Salisbury W.G. (Bill) Hefner VA Medical Center, Salisbury, NC - Salisbury, North Carolina, United States
- VA Roseburg Healthcare System, Roseburg, OR - Roseburg, Oregon, United States
- VA Southern Oregon Rehabilitation Center and Clinics, White City, OR - White City, Oregon, United States
- Ralph H. Johnson VA Medical Center, Charleston, SC - Charleston, South Carolina, United States
- Michael E. DeBakey VA Medical Center, Houston, TX - Houston, Texas, United States
- Michael E. DeBakey VA Medical Center, Houston, TX - Houston, Texas, United States
- Hampton VA Medical Center, Hampton, VA - Hampton, Virginia, United States
- Hunter Holmes McGuire VA Medical Center, Richmond, VA - Richmond, Virginia, United States
- Salem VA Medical Center, Salem, VA - Salem, Virginia, United States
- Spokane VA Medical Center, Spokane, WA - Spokane, Washington, United States
- Jonathan M. Wainwright Memorial VA Medical Center, Walla Walla, WA - Walla Walla, Washington, United States