Complex Molecular Etiology and Cellular Landscape of Hip Osteoarthritis
Recruiting · NCT05278520 · Observational (researchers observe without assigning treatment) · Lead sponsor: University of Turku
View the official record on ClinicalTrials.gov →Interventions studied
Total hip arthroplasty
What this trial is about
The purpose of this study is to cast light on the highly complex etiology and cellular landscape of hip osteoarthritis by utilising single-cell and spatial omics.
Who can take part
Age range
18 Years to 74 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- for the main (OA) study:
- Cases: Adult patients with osteoarthritis in the hip joint and who are going through an elective total hip arthroplasty.
- Controls: Non-arthritis adult patients who are going through a trauma-based emergency total hip arthroplasty.
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- Inclusion Criteria for the Rheumatoid sub-study:
- Adult patients with rheumatoid arthritis in the hip joint and who are going through an elective total hip arthroplasty.
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Exclusion criteria
- The body mass index must be below 35
- Age \< 18 or \> 74
- The OA patients may not have diabetes, rheumatoid arthritis (RA), or metabolic syndrome.
- For the Rheumatoid sub-study, the exclusion criteria are the same as above except for the RA.
Where it is running
8 locations listed.
- PET-centre, University of Turku - Turku, Southwest Finland, Finland
- Turku Bioscience, University of Turku - Turku, Southwest Finland, Finland
- Turku University Hospital - Turku, Southwest Finland, Finland
- PET-centre, University of Turku - Turku, Southwest Finland, Finland
- Turku Bioscience, University of Turku - Turku, Southwest Finland, Finland
- Turku University Hospital - Turku, Southwest Finland, Finland
- Helsinki University Hospital - Espoo, Uusimaa, Finland
- Helsinki University Hospital - Espoo, Uusimaa, Finland