Clinical trials recruiting for Osteoarthritis

Phase breakdown

Drugs and treatments being studied

Where trials are recruiting (top US states)

Top cities

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Recruiting trials

• "Bimodal vs Unimodal High-Intensity Pulsed Electromagnetic Field Therapy in Older Adults With Knee Osteoarthritis"
  NCT07198750 · Phase: Not applicable (e.g. observational or device study) · Ages: 60 Years and older · Sex: All (male and female) · 1 location
• "Effectiveness of Mulligan Mobilization Technique and Proprioceptive Exercises Among Patients With Knee Osteoarthritis"
  NCT06971016 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years and older · Sex: All (male and female) · 1 location
• "Transarterial Microembolization (TAME) in Inflammatory Knee Pathology"
  NCT07140367 · Phase: Not specified · Ages: 40 Years and older · Sex: All (male and female) · 1 location
• "Translating Articular Biomarkers Into Diagnoses"
  NCT06312943 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• 6-month Efficacy and Safety of Synolis VA 80/160 in Hip Osteoarthritis
  NCT05829733 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 3 locations
• 99Tc-MDP Treatment for Knee Osteoarthritis
  NCT02993029 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years and older · Sex: All (male and female) · 1 location
• A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain
  NCT07641517 · Phase: Phase 2 · Ages: 40 Years and older · Sex: All (male and female) · 37 locations
• A Clinical Study to Evaluate the Safety, Tolerability and Efficacy of BBM-A101 in the Treatment of Knee Osteoarthritis.
  NCT07198555 · Phase: Phase 1 · Ages: 40 Years to 75 Years · Sex: All (male and female) · 2 locations
• A Comparative Study on the Safety and Efficacy of the Intra-Articular Injectable Filler ALLOHEAL in Patients With Knee Osteoarthritis
  NCT07513415 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years to 80 Years · Sex: All (male and female) · 1 location
• A Decentralized Clinical Study Evaluating the Effectiveness of Two Different Doses of MyCondro™ on Physical Mobility and Joint Health
  NCT07493239 · Phase: Not applicable (e.g. observational or device study) · Ages: 45 Years and older · Sex: All (male and female) · 1 location
• A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
  NCT05986292 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · 64 locations
• A Mobile Intervention to Reduce Pain and Improve Health-III
  NCT06623669 · Phase: Phase 2 · Ages: 65 Years and older · Sex: All (male and female) · 1 location
• A Multi-Center Study Assessing the Safety and Efficacy of the LEGION Medial Stabilized (MS) Insert in Patients Undergoing a Total Knee Arthroplasty (TKA)
  NCT07199738 · Phase: Not specified · Ages: 18 Years to 80 Years · Sex: All (male and female) · 4 locations
• A Multi-centre Study of Shoe-worn Insoles and Knee Osteoarthritis
  NCT06251167 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years and older · Sex: All (male and female) · 1 location
• A Multicenter, Open-Label, Single-Arm Extension Study to Evaluate the Safety and Efficacy of FURESTEM-OA-Kit Inj. in Knee Osteoarthritis Patients Who Received Placebo in the K0701 Phase 2a Trial
  NCT07754175 · Phase: Not specified · Ages: 19 Years and older · Sex: All (male and female) · 2 locations
• A Multicenter, Postmarket Surveillance Study of Subjects With the Canary canturioTM te Tibial Extension
  NCT06040827 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 7 locations
• A Phase III Study of CLS2901C in Patients With Osteoarthritis of the Knee
  NCT06549686 · Phase: Phase 3 · Ages: 20 Years to 79 Years · Sex: All (male and female) · 6 locations
• A Phase Ib Study to Evaluate the Efficacy and Safety of HRS-2129 in Patients With Knee Osteoarthritis
  NCT07351968 · Phase: Phase 1 · Ages: 18 Years to 80 Years · Sex: All (male and female) · 1 location
• A Prospective Cohort Study of Patients Suffering From Hand Osteoarthritis Symptoms
  NCT03650673 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 60 Years · Sex: All (male and female) · 1 location
• A Prospective Total Joint Surgery Registry to Monitor Short- and Long-Term Clinical Outcomes
  NCT06687109 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• A Prospective, Post-Market, Clinical Follow-up Study of the Incompass™ Total Ankle System
  NCT07118501 · Phase: Not specified · Ages: 21 Years and older · Sex: All (male and female) · 5 locations
• A Prospective, Pre-market, Multi-center Study of Insignia Hip Stem in THA to Determine Implant Survivorship and PROMS.
  NCT06108934 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression
  NCT06906939 · Phase: Early Phase 1 · Ages: 50 Years to 95 Years · Sex: All (male and female) · 1 location
• A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
  NCT07481630 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 82 locations
• A Study of Econoglutide Injection in Obese Participants With Knee Osteoarthritis (KOA)
  NCT07734311 · Phase: Phase 3 · Ages: 18 Years to 75 Years · Sex: All (male and female) · 1 location
• A Study of FB1003 in Healthy and Osteoarthritis Pain Subjects
  NCT06343714 · Phase: Phase 1 · Ages: 18 Years to 75 Years · Sex: All (male and female) · 2 locations
• A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee
  NCT07153471 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 88 locations
• A Study to Assess Safety and Tolerability of PCRX-201 in Subjects With Painful Osteoarthritis of the Knee
  NCT06884865 · Phase: Phase 2 · Ages: 45 Years to 80 Years · Sex: All (male and female) · 40 locations
• A Study to Assess the Efficacy and Safety of Vutiglabridin in Knee Osteoarthritis Patients
  NCT06845553 · Phase: Phase 2 · Ages: 40 Years to 75 Years · Sex: All (male and female) · 1 location
• A Study to Compare Different Ways of Steroid Administration After Total Knee Implantation
  NCT04432012 · Phase: Phase 4 · Ages: 50 Years to 85 Years · Sex: All (male and female) · 1 location
• A Study to Evaluate the Efficacy and Safey of PTP-001 (MOTYS™) in Knee Osteoarthritis Patients
  NCT07219771 · Phase: Phase 3 · Ages: 40 Years to 80 Years · Sex: All (male and female) · 17 locations
• A Study to Investigate the Treatment Effect of Subcutaneous Injections of Pentosan Polysulfate Sodium Compared With Placebo in Adult Participants With Knee Osteoarthritis Pain.
  NCT06917404 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 56 locations
• ACB With S-ESPB Versus ACB With iPACK for Knee Arthroplasty
  NCT07288970 · Phase: Not applicable (e.g. observational or device study) · Ages: 65 Years to 100 Years · Sex: All (male and female) · 1 location
• AETOS Shoulder System
  NCT06319911 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 5 locations
• AI-Based Phenome Data Analysis for Predicting the Onset of Major Diseases
  NCT07595718 · Phase: Not specified · Ages: 30 Years to 60 Years · Sex: All (male and female) · 2 locations
• AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
  NCT07509307 · Phase: Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 81 locations
• ARVIS TKA vs Conventional TKA
  NCT06663384 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Activating SilverSneakers Benefits for Seniors With Osteoarthritis
  NCT06782347 · Phase: Not applicable (e.g. observational or device study) · Ages: 65 Years and older · Sex: All (male and female) · 1 location
• Acupuncture vs Sham Acupuncture for Hand Osteoarthritis
  NCT05267093 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 80 Years · Sex: All (male and female) · 1 location
• Acute Effects of Blood Flow Restriction Training to Failure on Hypoalgesia in Patients With Severe Knee Osteoarthritis Using Dynamic or Fixed Occlusion Pressure
  NCT07300384 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years to 85 Years · Sex: All (male and female) · 2 locations
• Acute Exercise Responses With Blood Flow Restriction Under Dynamic Pressure Compared to Fixed Pressure in Patients With Severe Gonarthrosis
  NCT07316933 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years to 85 Years · Sex: All (male and female) · 1 location
• Adapting Rehabilitation Delivery for Maximum Impact at Home-2 (ReDI-2)
  NCT07055113 · Phase: Not applicable (e.g. observational or device study) · Ages: No age limits stated · Sex: All (male and female) · 1 location
• Adductor Ratio in Severe Varus Gonarthrosis
  NCT05936814 · Phase: Not specified · Ages: 65 Years and older · Sex: All (male and female) · 1 location
• Adipose-Derived Biocellular Regenerative Therapy for Osteoarthritis
  NCT04238143 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 90 Years · Sex: All (male and female) · 2 locations
• Advanced Brain Imaging-TKA (fMRI-TKA)
  NCT07464080 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Allogenic Adipose-Derived Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis
  NCT06570291 · Phase: Phase 3 · Ages: 40 Years to 75 Years · Sex: All (male and female) · 2 locations
• Allogenic Mesenchymal Stem Cell Intraarticular Injection for Knee Osteoarthritis Therapy
  NCT05933434 · Phase: Phase 1, Phase 2 · Ages: 40 Years to 75 Years · Sex: All (male and female) · 1 location
• Alloplastic Total Temporomandibular Joint (TMJ) Replacement Registry
  NCT03991728 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 23 locations
• Altered Joint Mechanics and Biological Response in Osteoarthritic Knees.
  NCT07481461 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Amniotic Suspension Allograft Injection for Knee Osteoarthritis
  NCT06704893 · Phase: Phase 3 · Ages: 18 Years to 80 Years · Sex: All (male and female) · 2 locations
• An Artificial Intelligence-based Approach in Total Knee Arthroplasty: From Inflammatory Responses to Personalized Medicine
  NCT06634654 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• An Implementation Science Approach to Evaluating Self-Administered Acupressure for Knee Osteoarthritis in Older-Aged Adults in the Community
  NCT07329023 · Phase: Not applicable (e.g. observational or device study) · Ages: 60 Years and older · Sex: All (male and female) · 1 location
• An Open-Label, Double-Treatment Group Study to Evaluate the Efficacy and Safety of Human Allogeneic Bone-Marrow- Derived Mesenchymal Stromal Cell Product StromaForte Compared With Hyaluronic Acid for the Treatment of Knee Osteoarthritis
  NCT07542808 · Phase: Phase 2, Phase 3 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• An Study to Evaluate Safety and Tolerability of OA-SYS in Subjects With Moderate to Severe Osteoarthritis of the Knee Joint
  NCT06485843 · Phase: Phase 2 · Ages: 35 Years to 75 Years · Sex: All (male and female) · 1 location
• Analysis of Articular Biomarkers From Osteoarthritic Thumb Basal Joints
  NCT06370312 · Phase: Not specified · Ages: 25 Years and older · Sex: All (male and female) · 2 locations
• Analysis of Protein Expression in Serum of KOA Subjects
  NCT06553313 · Phase: Not applicable (e.g. observational or device study) · Ages: 50 Years and older · Sex: All (male and female) · 1 location
• Analysis of the Loss of Muscle Force, Power and Motor Control to Predict the Risk of Falls in Patients With Knee OA
  NCT06611618 · Phase: Not applicable (e.g. observational or device study) · Ages: 65 Years to 80 Years · Sex: All (male and female) · 1 location
• Analysis of the Pathophysiological and Functional State of the Knee Joint
  NCT06490770 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 60 Years · Sex: All (male and female) · 1 location
• Anatomic TSA vs RTSA for Glenohumeral Arthritis
  NCT04629391 · Phase: Not applicable (e.g. observational or device study) · Ages: 65 Years to 85 Years · Sex: All (male and female) · 1 location
• Anatomical Axis on X-Ray and Its Relationship With Pain and Kinesiophobia in Knee Osteoarthritis
  NCT07168590 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 2 locations
• Anti-Diabetic Drug, Exercise and Healthy Diet for Knee Osteoarthritis With Overweight/Obesity
  NCT07065591 · Phase: Early Phase 1 · Ages: 40 Years to 80 Years · Sex: All (male and female) · 2 locations
• Anti-Gravity Treadmill Gait Training for Knee Osteoarthritis
  NCT07813078 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years to 70 Years · Sex: All (male and female) · 1 location
• Antibiotic Impregnated Bone Graft to Reduce Infection in Hip Replacement.
  NCT05169229 · Phase: Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Antigravity Treadmill After Joint Arthroplasty
  NCT07040878 · Phase: Not applicable (e.g. observational or device study) · Ages: 60 Years to 75 Years · Sex: All (male and female) · 1 location
• Arthrosamid vs. Steroid for the Management of Knee Osteoarthritis
  NCT07489521 · Phase: Phase 4 · Ages: 18 Years to 100 Years · Sex: All (male and female) · 1 location
• ArtiBest for Knee Osteoarthritis
  NCT06994546 · Phase: Not applicable (e.g. observational or device study) · Ages: 35 Years to 85 Years · Sex: All (male and female) · 1 location
• Artificial Intelligence-Assisted Advanced Analysis of Knee Imaging and Outcome Prediction
  NCT07721116 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Assessing the Association Between WBCT PFJ Morphological Metrics and Knee Symptoms
  NCT07472088 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Autologous BMA vs Saline and LAM + LP-PRP vs Saline Evaluations in Knee OA
  NCT05517434 · Phase: Phase 2, Phase 3 · Ages: 30 Years and older · Sex: All (male and female) · 2 locations
• BFR Training and Knee Osteoarthritis
  NCT07590323 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years to 70 Years · Sex: All (male and female) · 1 location
• BioPoly® Partial Resurfacing Knee Implant IDE
  NCT06915363 · Phase: Not applicable (e.g. observational or device study) · Ages: 30 Years to 65 Years · Sex: All (male and female) · 4 locations
• Biologic Therapy to Prevent Osteoarthritis After ACL Injury
  NCT03968913 · Phase: Early Phase 1 · Ages: 18 Years to 35 Years · Sex: All (male and female) · 1 location
• Biomechanical Footwear as a Non-invasive Alternative and Supplement to Total Knee Replacement
  NCT04732962 · Phase: Not applicable (e.g. observational or device study) · Ages: 45 Years to 80 Years · Sex: All (male and female) · 2 locations
• Blood Flow Restriction Training in Knee Osteoarthritic Patients
  NCT07402408 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years to 60 Years · Sex: All (male and female) · 1 location
• Bone Marrow Aspirate Concentrate (BMAC) vs Corticosteroid Injection
  NCT05985785 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location
• Bone Marrow Aspirate Concentrate (BMAC)Treatment for Knee Osteoarthritis
  NCT04716803 · Phase: Not applicable (e.g. observational or device study) · Ages: 45 Years to 75 Years · Sex: All (male and female) · 1 location
• Bone Marrow Aspirate Concentrate Versus Triamcinolone Injection For Hip Osteoarthritis
  NCT04990128 · Phase: Phase 3 · Ages: 18 Years to 75 Years · Sex: All (male and female) · 1 location
• Bone Marrow Versus Adipose Tissue as a Cell Source for Infiltrative Treatment of Knee Osteoarthritis
  NCT06040957 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years to 75 Years · Sex: All (male and female) · 1 location
• Bowen Technique With Retro-walking on Hamstring Flexibility in Knee Osteoarthritis
  NCT07238751 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years to 60 Years · Sex: All (male and female) · 1 location
• Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis
  NCT06245109 · Phase: Phase 4 · Ages: 41 Years and older · Sex: All (male and female) · 1 location
• CBD for Knee Osteoarthritis
  NCT06414473 · Phase: Phase 1, Phase 2 · Ages: 40 Years to 75 Years · Sex: All (male and female) · 1 location
• CBD for Pain Following Orthopedic Shoulder Surgery
  NCT06381791 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• COMPARATIVE EFFECTIVENESS OF EXERCISE, COGNITIVE BEHAVIOURAL THERAPY, AND THEIR COMBINATION FOR PEOPLE WITH CHRONIC MUSCULOSKELETAL PAIN AND POOR SLEEP: SLEEPFIT TRIAL
  NCT07532070 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 4 locations
• COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty
  NCT06809998 · Phase: Phase 1, Phase 2 · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Can Digitally Delivered First-line Osteoarthritis Treatment Improve Equal Access to Care
  NCT06148779 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Cannabidiol (CBD) in Pain Reduction for Knee Osteoarthritis
  NCT05020028 · Phase: Phase 2, Phase 3 · Ages: 40 Years to 75 Years · Sex: All (male and female) · 1 location
• Cannabidiol for Postoperative Opioid Reduction in Primary Total Knee Arthroplasty
  NCT06234631 · Phase: Phase 2 · Ages: 18 Years to 80 Years · Sex: All (male and female) · 2 locations
• Cannabinoid Interactions With Central and Peripheral Pain Mechanisms in Osteoarthritis of the Knee
  NCT04992624 · Phase: Phase 2 · Ages: 21 Years to 75 Years · Sex: All (male and female) · 1 location
• Cannabinoids for Osteoarthritis Pain Effectiveness Trial
  NCT06878417 · Phase: Not applicable (e.g. observational or device study) · Ages: 40 Years to 80 Years · Sex: All (male and female) · 3 locations
• CapFlex PIP Implant RSA
  NCT05484089 · Phase: Not specified · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Capsaicin in Digital Osteoarthritis Versus Control
  NCT06444919 · Phase: Phase 4 · Ages: 18 Years and older · Sex: All (male and female) · 4 locations
• Cardiovascular Risk in Digital Osteoarthritis
  NCT05923736 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Ceramic Modular Dual Mobility in Primary Total Hip Arthroplasty (THA)
  NCT05547984 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 1 location
• Clinical Cohort Study of Knee Arthroplasty Assisted by Digital Technology
  NCT06010979 · Phase: Not specified · Ages: No age limits stated · Sex: All (male and female) · 1 location
• Clinical Efficacy and Safety of Robot-assisted Total Knee Arthroplasty
  NCT06856356 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 80 Years · Sex: All (male and female) · 1 location
• Clinical Evaluation and Cost-effectiveness Analysis of 3D Digital Surgery in Traumatology
  NCT06603831 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 80 Years · Sex: All (male and female) · 1 location
• Clinical Orthopaedic Data Bank (Acute and Chronic)
  NCT00411060 · Phase: Not specified · Ages: No age limits stated · Sex: All (male and female) · 1 location
• Clinical Outcomes Study of the Nexel Total Elbow
  NCT02469662 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years and older · Sex: All (male and female) · 11 locations
• Clinical Results and RSA Migration Analysis of the GLOBAL ICON - Stemless Anatomic Shoulder
  NCT04468178 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 80 Years · Sex: All (male and female) · 1 location
• Clinical Study of Acupuncture Treatment of Knee Osteoarthritis
  NCT06805188 · Phase: Not applicable (e.g. observational or device study) · Ages: 18 Years to 70 Years · Sex: All (male and female) · 1 location

Related conditions

Trials recruiting for Osteoarthritis often also study these conditions. Each links to its own recruiting-trial list.

Common questions

Are these trials free to join?

Study-related care in a clinical trial is usually provided at no cost to participants, and some trials reimburse travel. Costs vary by study - the trial team will explain what is and is not covered. Confirm this directly with them.

How do I know if I am eligible for Osteoarthritis trials?

Each trial lists inclusion and exclusion criteria. The screener above checks stated age and sex only. The full eligibility (your medical history, current medications, test results) is assessed by the study team. Open any trial to read its criteria, then contact the site.

Is this list complete?

No. For the full list, search ClinicalTrials.gov.