Electroclinical Correlation of Anxiety
Recruiting · NCT05393518 · Interventional (participants receive a specific treatment) · Lead sponsor: University Hospital, Bordeaux
View the official record on ClinicalTrials.gov →Interventions studied
Anxiety-induced taskNeuropsychiatric assessment
What this trial is about
Anxiety disorders have the highest prevalence among mental disorders and cause considerable individual and financial costs. Current treatments do not relieve mental suffering of many patients. Understanding neurobiological mechanisms involved in pathological anxiety is a major scientific challenge.
Who can take part
Age range
18 Years to 65 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Man or woman
- Aged 18 to 65;
- With drug-resistant epilepsy
- Benefiting from a phase II pre-surgical assessment with intracerebral electrophysiological exploration by stereo-EEG
- Meeting the DSM-5 diagnostic criteria for generalized anxiety disorder ("pathological" population) or not meeting the DSM-5 diagnostic criteria for generalized anxiety disorder ("control" population)
- WAIS IV full scale IQ \> 75 or IAG \> 81
- Affiliate or beneficiary of a social security scheme
- Giving free, informed consent in writing and signed by the participant and the investigator
Exclusion criteria
- Being unable to give personal consent
- Be subject to a measure of legal protection (curatorship, guardianship) or placed under judicial protection;
- Suffer from a chronic delusional disorder (eg: schizophrenia);
- Have a moderate or high risk of suicide assessed using the corresponding section of the structured psychiatric interview called "Mini International Neuropsychiatric Interview" (M.I.N.I. 7.0) or a score \> 2 on item 10 of the MADRS, assessing suicidal risk;
- Being pregnant or breastfeeding
- Have severe and / or decompensated somatic illness other than drug-resistant epilepsy
Where it is running
1 location listed.
- CHU de Bordeaux - Bordeaux, France