PRP in ACLR to Prevent PTOA
Recruiting · NCT05412381 · Interventional (participants receive a specific treatment) · Lead sponsor: Hospital for Special Surgery, New York
View the official record on ClinicalTrials.gov →Interventions studied
placebo saline injectionplatelet rich plasma (PRP) injection
What this trial is about
The purpose of our study is to examine the effect of platelet-rich-plasma (PRP) injection on the short-term resolution of post-injury inflammation (biomarkers) and improvement in joint function in patients with acute ACL injury. This RCT has been powered based on the questionnaire KOOS Jr. but it is considered a 'pilot study' in terms of the lab analysis proposed.
Who can take part
Age range
14 Years to 50 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 3
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Acute ACL injury within 6 weeks of presentation
- Age 14-50
- Male or female
- Meniscus injury that can be treated with meniscectomy or repair (the lack of meniscus injury will not exclude patients)
Exclusion criteria
- Prior ACL reconstruction
- Prior cartilage repair procedure
- Prior meniscus surgery within 12 months
- Prior steroid, hyaluronic acid, or PRP injection within 6 months
- Other ligament injury requiring repair
- Any cartilage lesion requiring repair
- Any cartilage lesion greater than grade 2 (partial thickness injury)
- History of inflammatory arthritis or joint sepsis
- Non English speakers
Where it is running
1 location listed across 1 US state.
- Hospital for Special Surgery - New York, New York, United States