The Mechanisms of Underlying Accelerated Repetitive Transcranial Magnetic Stimulation for Treatment-resistant Depression
Recruiting · NCT05607654 · Interventional (participants receive a specific treatment) · Lead sponsor: First Affiliated Hospital of Zhejiang University
View the official record on ClinicalTrials.gov →Interventions studied
active iTBSsham rTMS
What this trial is about
In this project, the investigators evaluate an accelerated schedule of repetitive transcranial magnetic stimulation for treatment-resistant depression. The investigators focuse on participants' brain activity and blood markers (Reelin, Apoer2, NMDAR, BDNF, exosomes and so on) to deepen the understanding of the mechanism of accelerated rTMS for treatment-resistant depression.
Who can take part
Age range
18 Years to 45 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- The current episode met the DSM-5 diagnostic criteria for major depression in patients with first-episode or relapsed unmedicated depression without psychotic symptoms.
- 24-item Hamilton Depression Scale (HAMD-24) ≥ 20.
- Age 18-45 years, regardless of gender.
- Right-handedness.
- Han Chinese.
- Signed a written informed consent, willing to participate in the study and be evaluated.
Exclusion criteria
- Co-morbid other mental disorders, including: schizophrenia, mental retardation, substance dependence, etc.
- Patients with metal objects in the body or with other contraindications to MRI scanning
- Patients with severe or unstable somatic diseases
- Women during pregnancy or lactation, and women of childbearing age with positive urine HCG test results during the screening period
- Other conditions that, in the opinion of the investigator, exist that make participation in this clinical trial inappropriate.
Where it is running
1 location listed.
- The First Affiliated Hospital of Zhejiang University - Hangzhou, Zhejiang, China