Alteration of Symbiosis Intestinal Microbiota on Patients With Anorexia Nervosa
Recruiting · NCT05632497 · Observational (researchers observe without assigning treatment) · Lead sponsor: Assistance Publique - Hôpitaux de Paris
View the official record on ClinicalTrials.gov →Interventions studied
Stool and blood samples
What this trial is about
The purpose of this study will be to study the association between the level of psychic symptomatic of anorexia nervosa (AN) (intensity of food restriction, symptoms of anxiety and depression) and alteration of host environment symbiosis and the mechanism (dysbiosis of intestinal microbiota, increase of intestinal permeability, immunity alteration and low-grade inflammation).
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- For patients:
- Patients aged ≥18 years;
- Anorexia according to DSM-5 and CIDI (Composite International Diagnostic Interview);
- Body mass index (BMI) (P/T2) \< 15;
- Hospitalization for nutrition rehabilitation;
- Covered by a health insurance;
- Informed consent form signed.
- For Healthy Volunteers:
- Aged ≥18 years;
- 18.5 \< BMI (P/T2) \< 25;
- Covered by a health insurance;
- Informed consent form signed.
Exclusion criteria
- For patients:
- Patients no-responding all criteria of DSM-5 or CIDI scores;
- Taken of antibiotic treatment 2 months / or laxativ 3 weeks before hospitalization;
- Somatic comorbidity should perturb intestinal microbiota (Crohn's disease, diabetes and all other chronic inflammatory diseases);
- Patients under guardianship;
- Patients covered by french AME scheme.
- For Healthy Volunteers:
- Any disease should perturb intestinal microbiota;
- Recent ponderal variation;
- Taken of antibiotic treatment 2 months or laxativ 3 weeks before hospitalization;
- Under guardianship;
- Covered by french AME scheme.
Where it is running
1 location listed.
- Service de Nutrition Clinique, Hôpital Paul Brousse (APHP) - Villejuif, France