Study of the Role of Genetic Modifiers in Hemoglobinopathies
Recruiting · NCT05799118 · Observational (researchers observe without assigning treatment) · Lead sponsor: Cyprus Institute of Neurology and Genetics
View the official record on ClinicalTrials.gov →Interventions studied
GWAS
What this trial is about
This study will investigate the role of genetic modifiers in hemoglobinopathies through a large-scale, multi-ethnic genome-wide association study (GWAS).
Who can take part
Age range
2 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Clinical diagnosis of an inherited hemoglobinopathy, including sickle cell disease (SCD), β-thalassemia, and α-thalassemia; all genotypes will be considered.
- Age ≥ 2 years old at the time of the collection of the phenotypic data.
- There will be no limits on study participants in terms of gender, ethnicity, morbidities.
Exclusion criteria
- Patients treated with stem cell transplantation or genetic therapy.
- Age \< 2 years old at the time of the collection of the phenotypic data.
- Patient or legal representative for minors unwilling or unable to give consent.
Where it is running
26 locations listed across 1 US state.
- Boston Children's Hospital - Boston, Massachusetts, United States
- University of Abuja - Abuja, Nigeria
- Emek Medical Centre - Afula, Israel
- Ampang Hospital - Ampang, Malaysia
- Hippokrateio Hospital of Athens - Athens, Greece
- Laiko General Hospital - Athens, Greece
- National and Kapodistrian University of Athens - Athens, Greece
- Universiti Kebangsaan Malaysia - Bangi, Malaysia
- Universiti Brunei Darussalam - Brunei, Brunei
- University of Buenos Aires - Buenos Aires, Argentina
- Centro Hospitalar e Universitário de Coimbra - Coimbra, Portugal
- Rigshospitalet - Copenhagen, Denmark
- Kaduna State University - Kaduna, Nigeria
- Centre Hospitalier Monkole - Kinshasa, Democratic Republic of the Congo
- Universiti Sains Malaysia - Kota Bharu, Malaysia
- University of Lahore - Lahore, Pakistan
- General Hospital of Larissa - Larissa, Greece
- Larnaca General Hospital - Larnaca, Cyprus
- University Hospitals Leuven - Leuven, Belgium
- Limassol General Hospital - Limassol, Cyprus
- Lucrecia Paím Maternity - Luanda, Angola
- Hospital Clínico San Carlos - Madrid, Spain
- Archbishop Makarios III Hospital - Nicosia, Cyprus
- Paphos General Hospital - Paphos, Cyprus
- University of Turin - Turin, Italy
- Ahmadu Bello University - Zaria, Nigeria