CSP #2026 - Beta Blocker Dialyzability on Cardiovascular Outcomes
Recruiting · NCT05931276 · Interventional (participants receive a specific treatment) · Lead sponsor: VA Office of Research and Development
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
The investigators aim to determine, using a point-of-care randomized controlled trial design, if hemodialysis patients, who are randomized to metoprolol succinate (a dialyzable, beta-1 selective beta blocker), have an improved cardiovascular outcome compared to those randomized to carvedilol (a non-dialyzable, non-selective beta blocker with alpha-1 antagonist properties). The investigators will also examine intervention practices to identify components that best support engagement and sustainability.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 3
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- On hemodialysis
- Received one of the following beta blockers through the VA pharmacy: metoprolol (succinate or tartrate), atenolol, labetalol, carvedilol, bisoprolol
Exclusion criteria
- Impaired decision-making capacity
- Patients not receiving carvedilol who have a history of asthma
- known hypersensitivity to any component of either drug
- Provider unwilling to sign a new medication order for a randomized patient
- No surrogate consent will be allowed
Where it is running
8 locations listed across 8 US states.
- VA Long Beach Healthcare System, Long Beach, CA - Long Beach, California, United States
- North Florida/South Georgia Veterans Health System, Gainesville, FL - Gainesville, Florida, United States
- Atlanta VA Medical and Rehab Center, Decatur, GA - Decatur, Georgia, United States
- Iowa City VA Health Care System, Iowa City, IA - Iowa City, Iowa, United States
- VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA - Boston, Massachusetts, United States
- Minneapolis VA Health Care System, Minneapolis, MN - Minneapolis, Minnesota, United States
- Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE - Omaha, Nebraska, United States
- New Mexico VA Health Care System, Albuquerque, NM - Albuquerque, New Mexico, United States