Effect of Anti-inflammatory Diet in Osteoarthritis
Recruiting · NCT06080347 · Interventional (participants receive a specific treatment) · Lead sponsor: University of California, San Diego
View the official record on ClinicalTrials.gov →Interventions studied
Anti-inflammatory DietHealthy Diet
What this trial is about
In a previous exploratory study, the investigators observed an effect on disease activity outcomes of anti-inflammatory diet. The investigators also observed change in microbiome and circulating metabolites. The current study will determine whether or not the addition of anti-inflammatory diet improves the clinical outcomes in participants with Osteoarthritis, and the role of microbiome and circulating metabolites.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Unilateral radiographic symptomatic KOA
- No changes in therapy during the previous 3 months
- Interested in dietary intervention and able to provide consent and attend follow-up visits
Exclusion criteria
- Previous knee surgery
- Severe radiographic disease (KL grade 4)
- Rheumatoid Arthritis
- Any Abnormal blood values in the comprehensive metabolic panel test at screen (Abnormality will be defined based on standard reference ranges)
- Use of corticosteroids and/or intra-articular injections during the preceding 3 months
- Use of fish oils and glucosamine
- Participation in a weight loss program in the preceding 6 months
- Recent changes in physical activity levels
- Regular smoking
- Patients with food allergies
- Patient with other medical conditions that will impair the ability to participate in a nutritional study
- Plan to change systemic therapy
- Patients unwilling to change dietary habits
Where it is running
1 location listed across 1 US state.
- University of California - San Diego, California, United States