Oscillatory Activity in Basal Ganglia Circuits During Normal and Pathological Movement
Recruiting · NCT06241924 · Interventional (participants receive a specific treatment) · Lead sponsor: University Hospital, Bordeaux
View the official record on ClinicalTrials.gov →Interventions studied
High Resolution Electroencephalogram (EEG-HR)Stereo-electro-encephalography (SEEG)
What this trial is about
The expression of hypokinetic and hyperkinetic motor symptoms is accompanied by pathological synchronous oscillations of neuronal activity in this cortico-subcortical network with a wide frequency range. The purpose of this research is to study cortico-subcortical oscillations and their synchronization in two pathologies emblematic of hypokinetic (Parkinson's disease) and hyperkinetic (epilepsies) phenomena using a simple motor task and comparing different situations.
Who can take part
Age range
18 Years to 75 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Male or Female
- Between 18 and 75 years of age
- With Parkinson's disease and already operated with implantation of electrodes in the Subthalamic nucleus connected to a PERCEPT (TM) device.
- Giving free, informed, written consent signed by the participant and the investigator Or
- With drug-resistant epilepsy and benefiting from a phase II pre-surgical assessment with intracerebral electrophysiological exploration by stereo-EEG
- With at least one electrode exploring the basal ganglia or the thalamus.
- Able to perform the simple motor task
- Affiliated or beneficiary of a social security scheme;
- Giving free, informed, written consent signed by the participant and the investigator
Exclusion criteria
- Be incapable of giving consent personally
- Be subject to a legal protection measure or be placed under judicial protection;
- Being pregnant or breastfeeding
- Present a serious and/or decompensated somatic or psychiatric illness
Where it is running
1 location listed.
- CHU de Bordeaux - Bordeaux, France