Effect of Blue Light on Vagus Nerve Stimulation in Patients With Refractory Epilepsy
Recruiting · NCT06304389 · Interventional (participants receive a specific treatment) · Lead sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Vagus nerve stimulation (VNS) is an adjunctive treatment for refractory epilepsy. Although widely used, there is still a substantial number of patients with insufficient response. Light, and particularly blue light, can stimulate alertness, attention and cognition through modulation of anatomical targets which are common to the vagal afferent network. This project aims at understanding how exposure to blue enriched light may influence VNS effects in patients with refractory epilepsy by exploring the modulation of a series of biomarkers of VNS action. This could possibly lead to new therapeutic strategies to increase efficacy of VNS.
Who can take part
Inclusion criteria
- Patients:
- VNS implanted since at least 3 months age \>18-60 years; IQ \>55 on Wechsler scale (normal status or mild cognitive impairment)
- healthy participants aged between 18 and 35 years without any medical history (neurological / psychiatric disease)
Exclusion criteria
- Patients:
- ther medical implanted devices than VNS, ocular diseases
- Helthy participants:
- medical implanted devices, cerebral trauma, ocular disease
Where it is running
1 location listed.
- Cliniques Universitaires Saint Luc - Woluwe-Saint-Lambert, Belgium