Comparing Efficiency of Mirogabalin and Pregabalin in Primary TKA
Recruiting · NCT06328062 · Interventional (participants receive a specific treatment) · Lead sponsor: Thammasat University Hospital
View the official record on ClinicalTrials.gov →Interventions studied
MirogabalinPregabalin
What this trial is about
The goal of this RCT is to compare efficacy between mirogabalin and pregabalin in pain reducing after unilateral primary total knee arthroplasty. The main question\[s\] it aims to answer are: • Does mirogabalin have better pain reduction than pregabalin after unilateral primary total knee arthroplasty. Participants will randomized to mirogabalin or pregabalin group and will take the drug for 2 weeks after TKA. Researchers will compare to pregabalin group to see pain and functional outcomes after TKA.
Who can take part
Age range
50 Years to 85 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Age 50-85 years old
- Unilateral primary osteoarthritis undergoing primary TKA
- ASA I-III
Exclusion criteria
- GFR \<60
- Allergy to drug in this study
- Cannot underwent spinal anesthesia and adductor canal block
- Taking gabapentinoid within 3 months before surgery
- History of previous knee surgery
- Severe liver disease
Where it is running
1 location listed.
- Thammasat University Hospital - Khlong Luang, Changwat Pathum Thani, Thailand