Physiology and Pathologies Linked to Human Splenic Function : Direct and Ex-vivo Perfusion Explorations
Recruiting · NCT06418256 · Observational (researchers observe without assigning treatment) · Lead sponsor: Assistance Publique - Hôpitaux de Paris
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Human splenic physiology remains poorly understood due to lack of functional exploration. However, through its ability to recognize alterations or modifications in circulating cells and to trigger an innate and adaptive response in response to these anomalies, the spleen plays a central role in several diseases affecting blood cells, directly or indirectly. The analysis of the splenic clearance of abnormal cells during ex-vivo perfusions made it possible to clarify the pathogenesis of malaria and the role of the spleen in the adaptive immune response. The study's investigative team wishes to extend these explorations to other human diseases in which the spleen is involved, and to evaluate the preventive or curative potential of substances that can modify the perception of blood cells by the spleen (e.g. monoclonal antibodies directed against circulating cells, among other options).
Who can take part
Inclusion criteria
- Adult patients
- Patient requiring left splenopancreectomy or planned splenectomy regardless of the method or indication
Exclusion criteria
- \- The patient notified his doctor of his refusal to recover his spleen and blood volume
Where it is running
5 locations listed.
- Hôpital Beaujon - Clichy, France
- Hôpital Saint Antoine - Paris, France
- Hôpital Pitié Salpêtrière - Paris, France
- Hôpital Necker-Enfants Malades - Paris, France
- Institut Pasteur - Paris, France