IV Ketamine vs. IN Esketamine for MDD TRD
Recruiting · NCT06488586 · Observational (researchers observe without assigning treatment) · Lead sponsor: Gustavo Vazquez
View the official record on ClinicalTrials.gov →Interventions studied
Low dose IV Ketamine vs. IN Esketamine
What this trial is about
The goal of this observational study is to learn about the comparative acute effects of ketamine vs esketamine in participants over the age of 18 for the treatment of their severe depression and suicidal ideations. Participants are already taking antidepressants and/or antipsychotics as part of their regular medical care for depression,
Who can take part
Age range
18 Years to 75 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Adult outpatients (18-75 years old) with unipolar depression experiencing major depressive episodes as determined by the DSM5 and characterized as MDD-TRD (diagnosed with major depressive disorder as outlined by the DSM5) and experienced at least two previous failed antidepressant treatments of adequate dose and duration for the current episode
Exclusion criteria
- Individuals with psychosis, main diagnosis of personality disorder, uncontrolled hypertension, substance abuse, currently pregnant or breastfeeding, or who had a previous negative reaction to ketamine or esketamine, were ineligible to receive IV ketamine or IN esketamine.
Where it is running
1 location listed.
- Providence Care Hospital - Kingston, Ontario, Canada