Creating a Global Research Database That Connects Genetic Information and Long-term Health Data to Improve Personalized Treatment for People With Serious Mental Illness
Recruiting · NCT06641726 · Observational (researchers observe without assigning treatment) · Lead sponsor: Akrivia Health
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
This observational study aims to provide new insights into the nature and classification of severe mental illness and dementias that in time should help improve diagnostic practise, and enable the development of new and improved treatments. The investigators will achieve aims by gathering information and biological samples from over 50,000 research participants and then linking this information with participants' electronic health records, genetic and other potential markers of mental illnesses (called biomarkers, derived from biological samples). The investigators will use this resource to analyse how potential risk factors - genetic, other biological and non-biological (related to the participants' life circumstances) - influence participants' experiences, symptoms, and outcomes (both mental and physical health). The investigators will also use advanced analysis to assess whether there may be better ways of grouping together and understanding the experiences of those with severe mental illnesses and dementias. Given the value and importance of this resource for advancing mental health research, the investigators will also make the data available to other researchers to pursue these broad research aims.
Who can take part
Inclusion criteria
- \- All participants must have an electronic health record in a primary or secondary care service.
- Mental Health cohort(s) • Have received a diagnosis and/or treatment/referral for mental illness for MDD, BD, Schizophrenia.
- Having an available electronic health record
- Current age 18+ (no upper age limit)
- Can speak English Dementia cohort
- Participants aged 18+ (no upper age limit)
- Currently alive and are, or have been, old age psychiatry patients
- Received relevant diagnosis or referral:
- EITHER
- Clinical diagnosis of dementia, mild cognitive impairment (MCI) or subjective cognitive impairment (SCI) OR
- Memory clinic referral
- Must be willing and able to complete a validated cognitive assessment (MoCA or SLUMS).
- All dementia patients will undergo the extended biomarker analysis.
Exclusion criteria
- \- Mental Health cohort(s)
- Patients without capacity to provide consent. Dementia cohort
- Inability to understand spoken and/or written spoken English
- Individuals with intellectual disability.
- Patients with dementia in Creutzfeldt-Jakob disease (CJD), Huntington's, HIV dementia, alcohol-related dementia, intellectual disability, traumatic brain injury at any time.
- Patients diagnosed with depression (only an exclusion criterion for MCI/SCI patients), psychosis, bipolar disorder prior in the pre-index period - to be checked at screening.
Where it is running
1 location listed.
- GlobalMinds central study team - Oxford, Oxford, United Kingdom