Treating Loneliness In The Older Adult With Depression With tDCS
Recruiting · NCT06658795 · Interventional (participants receive a specific treatment) · Lead sponsor: Guangzhou Psychiatric Hospital
View the official record on ClinicalTrials.gov →Interventions studied
Sham stimulation groupTranscranial direct current stimulation (tDCS) on the Left DLPFCTranscranial direct current stimulation (tDCS) on the right VLPFC
What this trial is about
High loneliness is prevalent among older adults and is a significant risk factor for major depression and low recovery rates in patients. Current interventions for loneliness are limited. Previous research has demonstrated a link between loneliness, negative social emotions, and reduced resting-state functional connectivity in the lateral prefrontal cortex (LPFC) and the default mode network (DMN). Transcranial direct current stimulation (tDCS) has shown promise in enhancing emotional regulation and connectivity, potentially alleviating loneliness in older adults with depression.
Who can take part
Age range
60 Years to 80 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- High loneliness (UCLA Loneliness Scale \> 43).
- Diagnosis of major depressive disorder confirmed by the Structured Clinical Interview for DSM-5 Disorders.
- absence of suicidal ideation (Hamilton Depression Scale item 3 score ≤ 1).
Exclusion criteria
- Severe neurological diseases.
- Bipolar disorder, schizophrenia, addiction, or impulse control disorders.
- Contraindications for tDCS or MRI (e.g., metal implants).
- Presence of suicidal ideation.
Where it is running
1 location listed.
- Guangzhou Brain Hospital - Guangzhou, Guangdong, China