Sleep TMS for Depression
Recruiting · NCT06824415 · Interventional (participants receive a specific treatment) · Lead sponsor: Stanford University
View the official record on ClinicalTrials.gov →Interventions studied
TMS
What this trial is about
The goal of this study is to establish the feasibility, tolerability, and preliminary efficacy of sleep-state transcranial magnetic stimulation (TMS) for enhancing plasticity in depression treatment.
Who can take part
Age range
18 Years to 65 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Adults ages 18-65 years
- Current Major Depressive Disorder (MDD) diagnosis
- Failed ≥1 antidepressant medication
- Moderate-to-severe depression
- Stable antidepressant medication dose for ≥ 6 weeks prior to enrollment
- Healthy control participants are adults ages 18-65 years without current MDD symptoms, not taking antidepressant or antipsychotic medications, and without major psychiatric, neurological, substance use, medical conditions affecting brain function, or TMS/MRI contraindications.
Exclusion criteria
- Intellectual disability
- Significant head injury/neurological disorder
- Pregnancy or postpartum
- TMS/MRI contraindications
- Active substance use/suicidal ideation
Where it is running
1 location listed across 1 US state.
- Stanford University - Stanford, California, United States