Treatment of Anaemia After Caesarean With Intravenous Versus Oral Iron and Postpartum Depression

Inclusion criteria

• Age ≥18 years
• Caesarean delivery (elective or in emergency)
• Gestational age at delivery ≥ 32 weeks
• 8.0 g/dL ≤ postoperative Hb level ≤ 10.0 g/dL measured within 72 hours postpartum
• Informed consent form signed
• Hospitalization in the postpartum maternity ward
• National social security coverage including AME
• Inclusion criteria:
• Ferritinemia ≤ 100 ng/mL OR transferrin saturation ≤ 20% measured after postoperative Hb level measurement
• EPDS score in the immediate postpartum \<11 with a "never" answer to question n°10

Exclusion criteria

• Stillbirth or neonatal death
• Last body weight available before inclusion (measured at the end of pregnancy or in postpartum) \< 35kg or \> 100kg
• Biermer disease
• Hemochromatosis
• Homozygous sickle cell disease or thalassemia
• Chronic iron supplementation (outside pregnancy)
• Known hypersensitivity or allergy to the studied drugs (IV or oral iron)
• Contra-indication to the studied drugs (IV or oral iron)
• Severe asthma (with daily background treatment)
• Any known severe renal or liver disorder
• Active acute infection
• Diagnosis of schizophrenia or physical and intellectual state incompatible with a reliable self-evaluation
• Women currently treated with medication or with Electro Convulsion Therapy (ECT) for depression or bipolar disorders
• Participation in another clinical trial involving an intervention with the following risks:
• A change (increase or decrease in value) in Haemoglobin measured at 2 months postpartum OR
• A change in EPDS score measured at 2 and 6 months postpartum OR
• A trial exploring an intervention with a specific anaphylactic risk (reported as a potential adverse events in the protocol of the other trial) administered during the postpartum hospitalization period.
• Poor understanding of the French language
• Legal protection (curatorship or tutorship)