Neuroimmunology Registry and Biobank
Recruiting · NCT06958341 · Observational (researchers observe without assigning treatment) · Lead sponsor: Charite University, Berlin, Germany
View the official record on ClinicalTrials.gov →What this trial is about
A variety of antineuronal antibodies have been detected in the cerebrospinal fluid (CSF) of patients with neurological diseases. This raises the question of whether these antibodies are disease-specific or merely an epiphenomenon of inflammatory processes in the brain. The registry was established with the following objectives: \[1\] Are antineuronal antibodies much more common than previously thought in various neurological disorders for which the etiology has not yet been elucidated? \[2\] Can further correlations, such as those between HSV infection and NMDA receptor autoimmunity, be identified? \[3\] Are these antibodies mainly non-specific epiphenomena or are they crucial for the pathogenesis? \[4\] What is the clinical course of patients with antineuronal antibodies and their response to therapy? These questions will be addressed in a broad immunohistological screening of a large number of CSF samples and a clinical database of patients with neurological disorders.
Who can take part
Inclusion criteria
- Differential diagnosis: suspected neuroimmunological disease in which a lumbar puncture is indicated for further diagnosis and treatment decision
- Individuals with unclear clinical diagnosis where additional CSF is to be collected for isolation of B cells and production of monoclonal antibodies. The clinical condition of the patients and his/her compliance have to allow an extra 2-3 ml of CSF to be collected.
- Age: all age groups
- Gender: patients of both sexes will be included
Exclusion criteria
- \[1\] Withdrawal of consent
Where it is running
4 locations listed.
- Universität Ulm - Ulm, Germany
- Universität Ulm - Ulm, Germany
- Charité - Universitätsmedizin Berlin - Berlin, State of Berlin, Germany
- Charité - Universitätsmedizin Berlin - Berlin, State of Berlin, Germany