Correlation Between Serum Uric Acid, Serum Homocysteine Level and Interleukin- 17 in Lupus Nephritis Patients
Recruiting · NCT07017868 · Observational (researchers observe without assigning treatment) · Lead sponsor: Sohag University
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Systemic lupus erythematosus (SLE) is a chronic inflammatory multisystem autoimmune disease characterized by pathogenic autoantibodies production against nuclear structures . SLE affecting mainly women of childbearing age and is characterized by unpredictable flares and remissions. Disease severity varied from a mild episodic disorder to a rapidly progressive life-threatening illness. The kidney is the most commonly involved visceral organ in SLE. Therefore, identifying new noninvasive biomarkers of LN severity and outcome is mandatory. IL-17 is a potent pro-infammatory cytokine that amplifes T-cell activation and stimulates fibroblast cells, endothelial, and epithelial cells to produce several pro-infammatory mediators, including IL-1β, IL-6, and TNF-α. IL-17 receptor signaling enhances the expression of multiple pro-infammatory mediators. Hence, IL-17 enhances the production of neutrophil-attracting chemokines
Who can take part
Inclusion criteria
- ● Aged ≥18 years.
- SLE patients fulfilling the SLE International Collaborating Clinics (SLICC) classification criteria and matched controls.
- Patients cooperative and can answer questions.
- Patients who are able and willing to give written informed consent
Exclusion criteria
- ● Individuals with other autoimmune diseases.
- Patients receive any hyperuricemia treatment
- Pregnancy
- Malignancy
- Diabetes.
- Hypertension.
- Heart failure.
- Hepatic diseases.
- Chronic renal failure other than lupus nephritis.
- Renal artery stenosis.
- Renal vein thrombosis.
- Intrarenal arteriovenous fistula.
- Obstructive nephropathy.
- Urinary tract obstruction that could affect RI of intra renal arteries.
- Uncooperative patients.
- Patients not able and willing to give written informed consent.
Where it is running
1 location listed.
- Sohag university Hospital - Sohag, Egypt