The Perioperative Outcome of Epinephrine Infusion and Tranexamic Acid in Knee Arthroplasty Surgery
Recruiting · NCT07089251 · Interventional (participants receive a specific treatment) · Lead sponsor: King Abdullah International Medical Research Center
View the official record on ClinicalTrials.gov →Interventions studied
Tranexamic Acid (TXA) treatmentlow-dose epinephrine and tranexamic acid
What this trial is about
The aim of this clinical trial is to evaluate the effect of administering low-dose epinephrine and tranexamic acid on perioperative blood loss, thromboembolic complications, and hospitalization duration in patients undergoing knee joint arthroplasty. Also aim to evaluate the effect of administering low-dose epinephrine and tranexamic acid on perioperative thromboembolic complications, and hospitalization duration
Who can take part
Age range
18 Years to 70 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 4
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Patients undergoing knee joint arthroplasty.
- Saudi and Non-Saudi Patient.
- Patients who have Complete medical record.
Exclusion criteria
- End stage renal disease
- Liver cirrhosis
- Coagulopathy
- Pre-operative Hgb \<10 5.
- History of cerebrovascular accident or myocardial infarction in past 12 months.
- History of Heart failure.
- History of arrhythmia.
- History of pheochromocytoma, thyrotoxicosis and glaucoma.
- Pregnancy or breast feeding
- History of Deep venous thrombosis or pulmonary embolism
- Allergy to epinephrine or tranexamic acid
Where it is running
1 location listed.
- King Abdulaziz Medical City, Ministry of National Guard - Health Affairs - Riyadh, Riyadh Region, Saudi Arabia