A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee
Recruiting · NCT07153471 · Interventional (participants receive a specific treatment) · Lead sponsor: Eli Lilly and Company
View the official record on ClinicalTrials.gov →Interventions studied
OrforglipronPlacebo
What this trial is about
The GZPT master protocol will support two independent studies, J2A-MC-GZT1 and J2A-MC-GZT2. Each study will see how well and safely orforglipron works in people with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last about 74 weeks.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 3
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Have a body mass index (BMI) of 27 kilograms per square meter (kg/m2) or higher at screening
- Have tried at least once to lose weight through diet but were unsuccessful
- Have osteoarthritis of the knee and at least one of the following conditions:
- Be over 50 years old
- Have morning knee stiffness that lasts about 30 minutes
- Have a crackling or grinding sound or feeling in the knee
Exclusion criteria
- Have gained or lost more than 11 pounds within 90 days prior to screening
- Have had a surgery for obesity or plan to have one in the next 18 months
- Have an active knee infection
- Have type 1 diabetes, type 2 diabetes, or any other type of diabetes
- Have had a recent heart condition or New York Heart Association Functional Classification Class IV congestive heart failure
- Have used any glucagon-like peptide-1 (GLP-1) receptor agonist medication within 180 days of screening
Where it is running
60 locations listed across 17 US states.
- Arizona Research Center - Phoenix, Arizona, United States
- AMR Clinical - Tempe, Arizona, United States
- Care Access - Huntington Beach - Huntington Beach, California, United States
- Care Access - Thousand Oaks - Thousand Oaks, California, United States
- Legacy Clinical Trials - Colorado Springs, Colorado, United States
- Chase Medical Research, LLC - Waterbury, Connecticut, United States
- Care Access - Decatur - Decatur, Georgia, United States
- North Georgia Clinical Research - Woodstock, Georgia, United States
- Northwestern University - Chicago, Illinois, United States
- AMR Clinical - Newton, Kansas, United States
- MedVadis Research Corporation - Waltham, Massachusetts, United States
- StudyMetrix Research - City of Saint Peters, Missouri, United States
- AMR Clinical - Kansas City, Missouri, United States
- Cardio Metabolic Institute - Somerset, New Jersey, United States
- Carolina Research Center - Shelby, North Carolina, United States
- University Orthopedics Center - Altoona, Pennsylvania, United States
- Care Access - Rapid City - Rapid City, South Dakota, United States
- AMR Clinical - Knoxville, Tennessee, United States
- Mercy Family Clinic - Dallas, Texas, United States
- Juno Research - Houston, Texas, United States
- Biopharma Informatic, LLC - Houston, Texas, United States
- Activian Clinical Research - Kingwood, Texas, United States
- Advanced Rheumatology of Houston - Woodlands - The Woodlands, Texas, United States
- Charlottesville Medical Research - Charlottesville, Virginia, United States
- Gershon Pain Specialists - Virginia Beach, Virginia, United States
- Northwest Clinical Research Center - Bellevue, Washington, United States
- Hospital San Rafael - La Coruña - A Coruña, Spain
- The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technolo -T - Baotou, China
- Hospital Universitari Vall d'Hebron - Barcelona, Spain
- Xuanwu Hospital Capital Medical University - Beijing, China
- Siteworks GmbH - Bochum - Bochum, Germany
- Aggarwal and Associates Limited - Brampton, Canada
- Investigacion y Biomedicina de Chihuahua - Chihuahua City, Mexico
- The Second Affiliated Hospital Chongqing Medical University - Chongqing, China
- Centro de Estudios de Investigacion Metabolicos y Cardiovasculares, S.C. - Ciudad Madero, Mexico
- Klinische Forschung Dresden - Dresden, Germany
- Hamanomachi Hospital - Fukuoka, Japan
- Fukuoka Wajiro Hospital - Fukuoka, Japan
- HRF II - Hamburger Rheuma Forschungszentrum II MVZ für Rheumatologie und Autoimmunmedizin Hamburg GmbH / -T - Hamburg, Germany
- Klinische Forschung Hamburg - Hamburg, Germany
- Klinische Forschung Hannover-Mitte - Hanover, Germany
- Siteworks GmbH - Hannover - Hanover, Germany
- The Fourth Affiliated Hospital of Harbin Medical University - Harbin, China
- The Second People's Hospital of Hefei - Hefei, China
- Shimane University Hospital - Izumo, Japan
- Jinan Central Hospital - Jinan, China
- Diex Recherche Inc. Division Joliette - Joliette, Canada
- Kariya Toyota General Hospital - Kariya, Japan
- Klinische Forschung Karlsruhe - Karlsruhe, Germany
- Siteworks - Karlsruhe - Karlsruhe, Germany
- Ando Orthopedic - Kawasaki, Japan
- AmBeNet GmbH - Leipzig, Germany
- The First Affiliated Hospital of Henan University of Science &Technology - Luoyang, China
- Centro Medico del Angel - Mexicali, Mexico
- Tokyo Saiseikai Central Hospital - Minatoku, Japan
- Goto Orthopedic Surgery Clinic - Miyazaki, Japan
- IMED Internal Medicine Clin Trials - Monterrey, Mexico
- Clínica García Flores SC - Monterrey, Mexico
- Kato Orthopedic Clinic - Morioka, Japan
- Hospital Quirón Málaga - Málaga, Spain
Showing 60 of 88 listed sites. See the official record for the complete list.
Read the full protocol, contacts and eligibility on ClinicalTrials.gov →