Radiotherapy Compared to Corticosteroid Injection for Treatment of Hand Osteoarthritis

Recruiting · NCT07217405 · Interventional (participants receive a specific treatment) · Lead sponsor: Mayo Clinic

Interventions studied

Corticosteroid injection (CSI)Low-dose radiotherapy (LDRT)

The purpose of this research is to compare low-dose radiotherapy to corticosteroid injection for treatment of hand/wrist osteoarthritis.

Age range

50 Years and older

Sex

All (male and female)

Healthy volunteers

No - a diagnosis or condition is required

Phase

Phase 4

Study type

Interventional (participants receive a specific treatment)

Patient at Mayo Clinic, Rochester, MN
Age 50 years or older
Mild, moderate, or severe hand OA (Kellgren and Lawrence classification grade 2, 3, or 4) on hand radiographs within the last 24 months
Hand OA pain with a minimum VAS score relating to hand pain of ≥40 (on a 100-point scale) when using the affected hand
Ability to complete study questionnaires

History of previous surgery to the affected hand(s)
Autoimmune joint disease such as rheumatoid arthritis or psoriatic arthritis
Active confounding hand condition such as stenosing tenosynovitis or Dupuytren's contracture
Recent injury (within last 1 month) to the affected hand causing current pain
History of crystalline arthritis (gout or pseudogout) flare in the affected hand(s)
Active use of opioid pain medication(s) or oral steroids within the last 3 months
Fibromyalgia or central sensitization syndrome
Hand CSI or other hand injection within the past 3 months
History of hand LDRT within the past 3 months
Poorly controlled diabetes (HbA1c \> 10%)
Active infection
Current pregnancy

1 location listed across 1 US state.