Hippocampal Oscillations During Exploration
Recruiting · NCT07224191 · Interventional (participants receive a specific treatment) · Lead sponsor: NYU Langone Health
View the official record on ClinicalTrials.gov →Interventions studied
Ambulatory ExplorationVisual Exploration
What this trial is about
The objective of this study is to determine how visuomotor exploration relates to hippocampal activity along its long axis. The study will investigate the neurophysiological mechanisms in the hippocampus during (1) visual exploration in surgical patients using high-resolution iEEG, and (2) ambulatory exploration in patients implanted with RNS devices.
Who can take part
Age range
18 Years to 70 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- All subjects:
- Adults (18-70 years)
- Able to provide informed consent
- Aim 1: Surgical epilepsy patients' inclusion criteria
- Implanted hippocampal depth electrodes for Stage 1 epilepsy surgery
- MMSE\>=24
- Aim 2: RNS patients Inclusion criteria
- Implanted RNS device with at least one hippocampal depth electrode
- At least 5 months post-implantation to avoid the post-implant effect
- Have a relatively low number of seizures, defined as \<1 generalized tonic-clonic or other seizure with potential to fall or cause injury per month
- Able to walk and wear research equipment without assistance
- MMSE\>=24
- Aim 2: Healthy Control Inclusion criteria • Able to walk and wear research equipment without assistance
Exclusion criteria
- RNS patients, Aim 2:
- Any generalized tonic-clonic seizure within the last week
- All subjects:
- Legally blind
- Smoking tobacco, marijuana, recreational drugs or alcohol use within 1 week of cognitive testing
- Unable to give informed consent
- Pregnancy
Where it is running
1 location listed across 1 US state.
- NYU Langone Health - New York, New York, United States